The RNF123 Polyclonal Antibody (CAB7618) is a valuable tool for researchers studying the protein RNF123, a key player in the regulation of immune responses and protein degradation pathways. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By specifically targeting the RNF123 protein, this antibody enables the accurate detection and analysis of RNF123 expression across various cell types.RNF123 is a ubiquitin ligase protein that plays a crucial role in the degradation of target proteins involved in immune regulation and cell signaling.
Its involvement in protein turnover makes it a promising target for research into diseases such as cancer, autoimmune disorders, and inflammatory conditions. The RNF123 Polyclonal Antibody is an essential tool for researchers looking to investigate the functions and pathways associated with RNF123, providing valuable insights into potential therapeutic targets for immune-related diseases.
Product Name:
RNF123 Rabbit Polyclonal Antibody
SKU:
CAB7618
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1213-1314 of human RNF123 (NP_071347.2).
Sequence:
QSYA DYIS ADEL AQVE QMLA HLTS ASAQ AAAA SLPT SEED LCPI CYAH PISA VFQP CGHK SCKA CINQ HLMN NKDC FFCK TTIV SVED WEKG ANTS TTSS AA
Tested Applications:
WBELISA
Recommended Dilution:
WB,1:500 - 1:1000
Synonyms:
KPC1; FP1477; RNF123
Positive Sample:
A-549,Mouse brain,Mouse spleen
Conjugate:
Unconjugated
Cellular Localization:
Cytoplasm.
Calculated MW:
149kDa
Observed MW:
148kDa
The protein encoded by this gene contains a C-terminal RING finger domain, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions, and an N-terminal SPRY domain. This protein displays E3 ubiquitin ligase activity toward the cyclin-dependent kinase inhibitor 1B which is also known as p27 or KIP1. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
63891
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using RNF123 Rabbit pAb (CAB7618) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
