The RNF170 Polyclonal Antibody (CAB15196) is a valuable tool for researchers studying the RNF170 protein, which is involved in regulating protein degradation and turnover within cells. Raised in rabbits, this antibody is highly specific for human samples and has been validated for use in Western blot applications. By binding to RNF170, this antibody enables precise detection and analysis of the protein in a variety of cell types, making it an excellent choice for studies in cell biology and molecular biology.
RNF170, a member of the RING finger protein family, plays a crucial role in the ubiquitin-proteasome system, which is responsible for degrading unwanted or damaged proteins in the cell. Dysregulation of protein degradation pathways, including those involving RNF170, has been linked to various diseases such as neurodegenerative disorders and cancer. By understanding the function of RNF170, researchers can uncover potential therapeutic targets for these conditions and develop novel treatment strategies.
Product Name:
Rnf170 Rabbit Polyclonal Antibody
SKU:
CAB15196
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of mouse Rnf170 (NP_084241.1).
Predicted to enable metal ion binding activity and ubiquitin protein ligase activity. Predicted to be located in endoplasmic reticulum and membrane. Predicted to be integral component of membrane. Used to study hereditary ataxia. Human ortholog(s) of this gene implicated in autosomal dominant sensory ataxia 1. Orthologous to human RNF170 (ring finger protein 170).
Purification Method:
Affinity purification
Gene ID:
77733
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using Rnf170 Rabbit pAb (CAB15196) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
