The RPAP1 Polyclonal Antibody (PACO11897) is a valuable tool for researchers studying RPAP1, a protein involved in RNA polymerase II assembly and transcription regulation. This antibody, generated in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to RPAP1, this antibody enables accurate detection and analysis in a variety of cell types, making it an ideal choice for investigations in molecular biology and gene expression studies.RPAP1, also known as RNA polymerase II-associated protein 1, plays a crucial role in the assembly and function of RNA polymerase II, the enzyme responsible for transcribing messenger RNA.
By understanding the function and regulation of RPAP1, researchers can gain insights into fundamental processes of gene expression and potentially uncover new therapeutic targets for diseases related to transcription dysregulation.Overall, the RPAP1 Polyclonal Antibody (PACO11897) offers a reliable tool for researchers aiming to investigate the role of RPAP1 in transcriptional control and gene expression, providing valuable insights into molecular mechanisms underlying various physiological and pathological processes.
RNA polymerase II associated protein 1;RPAP1;DKFZp727M111;FLJ12732;KIAA1403;MGC858 ;
UniProt Protein Function:
RPAP1: Forms an interface between the RNA polymerase II enzyme and chaperone/scaffolding protein, suggesting that it is required to connect RNA polymerase II to regulators of protein complex formation. Required for interaction of the RNA polymerase II complex with acetylated histone H3. Belongs to the RPAP1 family. 3 isoforms of the human protein are produced by alternative splicing.Chromosomal Location of Human Ortholog: 15q15.1Cellular Component: nucleusMolecular Function: protein bindingBiological Process: transcription from RNA polymerase II promoter
UniProt Protein Details:
NCBI Summary:
This protein forms part of the RNA polymerase II (RNAPII) enzyme complex and may recruit RNAPII to chromatin through its interaction with acetylated histones. [provided by RefSeq, Jul 2012]
