The RRAD Polyclonal Antibody (PAC023803) is a valuable tool for research involving RRAD, a protein involved in regulating glucose metabolism and insulin signaling pathways. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. By binding to the RRAD protein, this antibody allows for precise detection and analysis in a variety of cell types, making it an excellent choice for studies in metabolism, diabetes, and cancer research.RRAD, also known as Ras-related associated with diabetes, is a key player in mediating glucose uptake and insulin sensitivity in cells.
Dysregulation of RRAD expression has been implicated in insulin resistance, making it a promising therapeutic target for metabolic disorders such as diabetes. Research into the function of RRAD is critical for understanding the molecular mechanisms underlying these conditions and developing targeted treatments to improve patient outcomes.Overall, the RRAD Polyclonal Antibody is a reliable tool for investigating the role of RRAD in cellular metabolism and insulin signaling pathways, providing valuable insights into metabolic disorders and potential therapeutic interventions.
Synthesized peptide derived from internal of human RAD.
Form:
Liquid
Storage Buffer:
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Western blot analysis of extracts from HeLa cells, HepG2 cells and MCF-7 cells, using RAD antibody.
Immunofluorescence analysis of A549 cells, using RAD antibody.
Immunohistochemistry analysis of paraffin-embedded human heart tissue using RAD antibody.
Background:
May play an important role in cardiac antiarrhythmia via the strong suppression of voltage-gated L-type Ca2+ currents. Regulates voltage-dependent L-type calcium channel subunit alpha-1C trafficking to the cell membrane By similarity. Inhibits cardiac hypertrophy through the calmodulin-dependent kinase II (CaMKII) pathway. Inhibits phosphorylation and activation of CAMK2D.
Synonyms:
GTP-binding protein RAD; RAD; RAD1; RAS associated with diabetes;
UniProt Protein Function:
RRAD: a small G protein of the RGK family. May play an important role in cardiac antiarrhythmia via the strong suppression of voltage-gated L-type Ca(2+) currents. Regulates voltage-dependent L-type calcium channel subunit alpha- 1C trafficking to the cell membrane. Inhibits cardiac hypertrophy through the calmodulin-dependent kinase II (CaMKII) pathway. Interacts with calmodulin preferentially in the inactive, GDP-bound form. Interacts with CAMK2D and CACNB2. Interaction with CACNB2 regulates the trafficking of CACNA1C to the cell membrane. Most abundantly expressed in the heart. Also found in the skeletal muscle and lung. Lesser amounts in placenta and kidney. Also detected in adipose tissue. Overexpressed in muscle of type II diabetic humans.Protein type: G protein, monomeric, RGK; G protein; G protein, monomericChromosomal Location of Human Ortholog: 16q22Cellular Component: plasma membraneMolecular Function: calmodulin binding; GTPase activity; protein binding; GTP bindingBiological Process: metabolic process; small GTPase mediated signal transduction
