The RRM2 Monoclonal Antibody (CAB3424) is a high-quality antibody developed for reliable detection and analysis of target proteins. This antibody, developed in rabbits, shows high specificity and sensitivity for human samples, making it ideal for use in various research applications such as Western blotting.RRM2 is essential for maintaining genomic stability and is often dysregulated in cancer, making it a promising target for novel cancer therapies. By targeting RRM2, researchers can gain valuable insights into the mechanisms underlying cancer development and progression.
This antibody is validated for use in WB, ELISA applications and has demonstrated reactivity against Human, Mouse, Rat samples.
Product Name:
RRM2 Monoclonal Antibody
SKU:
CAB3424
Size:
20μL, 100μL
Reactivity:
Human, Mouse, Rat
Clone Number:
ARC0775
Conjugate:
Unconjugated
Immunogen:
Recombinant protein (or fragment).This information is considered to be commercially sensitive.
Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Synonyms:
R2, RR2, RR2M, C2orf48, RRM2
Positive Sample:
HeLa, A-375, Mouse liver, Rat liver
Cellular Localization:
Cytoplasm.
Calculated MW:
45kDa
Observed MW:
45kDa
This gene encodes one of two non-identical subunits for ribonucleotide reductase. This reductase catalyzes the formation of deoxyribonucleotides from ribonucleotides. Synthesis of the encoded protein (M2) is regulated in a cell-cycle dependent fashion. Transcription from this gene can initiate from alternative promoters, which results in two isoforms that differ in the lengths of their N-termini. Related pseudogenes have been identified on chromosomes 1 and X.
Purification Method
Affinity purification
Gene ID
6241
RRID
AB_2863055
Buffer Information
Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol and 0.05% BSA, preserved with proclin300 or sodium azide, pH 7.3.
Western blot analysis of various lysates using RAbGn2 Rabbit mAb (CAB3424) at 1：1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Exposure time: 1s.
