The SAMD9 Polyclonal Antibody (PACO20388) is a valuable tool for researchers studying SAMD9, a gene involved in the regulation of cell growth and division. This antibody, generated in rabbits, exhibits high reactivity with human samples and has been validated for use in various applications, including Western blotting. By binding specifically to the SAMD9 protein, this antibody enables the detection and analysis of SAMD9 expression in a range of cell types, making it an ideal choice for studies in molecular biology and cancer research.
SAMD9 is known to play a crucial role in controlling cell proliferation and ensuring genomic stability. Mutations in the SAMD9 gene have been linked to certain types of cancer and other genetic disorders, underscoring the importance of understanding its function. By elucidating the mechanisms by which SAMD9 impacts cell growth and division, researchers can gain insights that may lead to new therapeutic approaches for treating various diseases.
Antibody Name:
SAMD9 Antibody (PACO20388)
Antibody SKU:
PACO20388
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:1000-1:2000, IHC:1:25-1:100
Species Reactivity:
Human
Immunogen:
Synthetic peptide of human SAMD9
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO20388(SAMD9 Antibody) at dilution 1/35, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
This gene encodes a sterile α motif domain-containing protein. The encoded protein localizes to the cytoplasm and may play a role in regulating cell proliferation and apoptosis. Mutations in this gene are the cause of normophosphatemic familial tumoral calcinosis. Alternate splicing results in multiple transcript variants that encode the same protein.
Synonyms:
sterile α motif domain containing 9
UniProt Protein Function:
SAMD9: Defects in SAMD9 are the cause of normophosphatemic familial tumoral calcinosis (NFTC). NFTC is an uncommon life-threatening disorder characterized by massive periarticular, and seldom visceral, deposition of calcified tumors.Protein type: Unknown functionChromosomal Location of Human Ortholog: 7q21.2Cellular Component: intracellular membrane-bound organelle; cytoplasmMolecular Function: protein bindingDisease: Tumoral Calcinosis, Normophosphatemic, Familial
UniProt Protein Details:
NCBI Summary:
This gene encodes a sterile alpha motif domain-containing protein. The encoded protein localizes to the cytoplasm and may play a role in regulating cell proliferation and apoptosis. Mutations in this gene are the cause of normophosphatemic familial tumoral calcinosis. Alternate splicing results in multiple transcript variants that encode the same protein.[provided by RefSeq, Jul 2010]
