The SBNO2 Polyclonal Antibody (PAC048186) is a valuable tool for researchers studying the SBNO2 protein, a key regulator of cell signaling pathways involved in various cellular processes. This antibody, produced in rabbits, exhibits high specificity and sensitivity towards human samples, making it ideal for use in Western blot applications.SBNO2 is known for its role in modulating inflammatory responses and cell growth, making it a promising target for research in immunology and cancer biology. By binding to the SBNO2 protein, this antibody enables accurate detection and analysis in a wide range of cell types, providing valuable insights into the function of SBNO2 and its potential implications in disease pathology.
Furthermore, the robust validation of this antibody ensures reliable and reproducible results, making it a valuable asset for studies aiming to unravel the intricate mechanisms governing cellular function and disease development. Take advantage of the SBNO2 Polyclonal Antibody to advance your research and gain a deeper understanding of SBNO2's involvement in various physiological and pathological processes.
Antibody Name:
SBNO2 Antibody (PACO48186)
Antibody SKU:
PACO48186
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IF
Recommended Dilutions:
ELISA:1:2000-1:10000, IF:1:20-1:200
Species Reactivity:
Human
Immunogen:
Recombinant Human Protein strawberry notch homolog 2 protein (6-146AA)
Immunofluorescent analysis of HepG2 cells using PACO48186 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Background:
Acts as a transcriptional coregulator, that can have both coactivator and corepressor functions. Inhibits the DCSTAMP-repressive activity of TAL1, hence enhancing the access of the transcription factor MITF to the DC-STAMP promoter in osteoclast. Plays a role in bone homeostasis; required as a positive regulator in TNFSF11//RANKL-mediated osteoclast fusion via a DCSTAMP-dependent pathway. May also be required in the regulation of osteoblast differentiation (By similarity). Involved in the transcriptional corepression of NF-kappaB in macrophages. Plays a role as a regulator in the proinflammatory cascade.
Synonyms:
Protein strawberry notch homolog 2, SBNO2, KIAA0963
UniProt Protein Function:
SBNO2: Seems to have transcriptional repression activity in macrophages. Belongs to the SBNO family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Motility/polarity/chemotaxisChromosomal Location of Human Ortholog: 19p13.3Biological Process: transcription, DNA-dependent; regulation of inflammatory response; macrophage activation during immune response; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; bone mineralization
