The SerpinB11 Polyclonal Antibody (PAC017085) is a crucial tool for researchers studying SerpinB11, a serine protease inhibitor involved in regulating various cellular processes. This antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. By specifically binding to the SerpinB11 protein, this antibody enables accurate detection and analysis in a variety of cell types, making it an essential tool for investigations in cell biology and cancer research.SerpinB11, also known as Serine Protease Inhibitor B11, plays a significant role in controlling protease activity and maintaining cellular homeostasis.
Dysregulation of SerpinB11 has been implicated in various diseases, including cancer and inflammatory disorders, highlighting its importance as a potential therapeutic target. Further research into the functions of SerpinB11 is essential for developing novel treatments that target protease-mediated pathways implicated in disease progression.Order the SerpinB11 Polyclonal Antibody (PAC017085) today to advance your research in understanding the role of SerpinB11 in health and disease.
Gel: 8%SDS-PAGE,Lysate: 40 μg,,Primary antibody: PACO17085(SERPINB11 Antibody) at dilution 1/400 dilution,Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution,Exposure time: 30 seconds.
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO17085(SERPINB11 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: x200).
Background:
SerpinB11 (serpin peptidase inhibitor, clade B (ovalbumin), member 11), also known as EPIPIN or SERPIN11, is a 392 amino acid, cytoplasmic protein that belongs to the Ov-serpin subfamily and serpin family. Like other members of the serpin family, SerpinB11 has been identified as a noninhibitory intracellular protein. The gene encoding SerpinB11 maps to human chromosome 18, which houses over 300 protein-coding genes and contains nearly 76 million bases. There are a variety of diseases associated with defects in chromosome 18-localized genes, some of which include Trisomy 18 (also known as Edwards syndrome), Niemann-Pick disease, hereditary hemorrhagic telangiectasia, erythropoietic protoporphyria and follicular lymphomas.
Synonyms:
serpin peptidase inhibitor, clade B (ovalbumin), member 11 (gene/pseudogene)
UniProt Protein Function:
SERPINB11: Has no serine protease inhibitory activity, probably due to mutations in the scaffold impairing conformational change. Belongs to the serpin family. Ov-serpin subfamily. 3 isoforms of the human protein are produced by alternative splicing.Chromosomal Location of Human Ortholog: 18q21.33Cellular Component: extracellular spaceMolecular Function: serine-type endopeptidase inhibitor activity
