The SLC2A12 Polyclonal Antibody (PACO18006) is a valuable tool for research involving SLC2A12, a glucose transporter protein known for its role in glucose uptake and metabolism. This antibody, generated in rabbits, is highly specific and reactive with human samples, making it ideal for use in Western blot applications. It recognizes the SLC2A12 protein, allowing for accurate detection and analysis in various cell types.SLC2A12, also known as GLUT12, is a member of the glucose transporter family and is involved in glucose transport across cell membranes. Its expression has been linked to metabolic disorders, insulin resistance, and cancer development.
By studying the function and regulation of SLC2A12, researchers can gain insights into the mechanisms underlying these disease processes and potentially identify new therapeutic targets.This polyclonal antibody is a valuable tool for investigating the role of SLC2A12 in various physiological and pathological conditions, including diabetes, obesity, and cancer. Its high specificity and ability to detect SLC2A12 protein make it an essential reagent for studies aiming to elucidate the functions of this glucose transporter in health and disease.
Antibody Name:
SLC2A12 Antibody (PACO18006)
Antibody SKU:
PACO18006
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:1000-1:2000, IHC:1:50-1:100
Species Reactivity:
Human
Immunogen:
Synthetic peptide of human SLC2A12
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using PACO18006 at dilution 1/30. (Original magnification: x200).
Background:
Solute carrier family 2, facilitated glucose transporter member 12 is a protein that in humans is encoded by the SLC2A12 gene. SLC2A12 belongs to a family of transporters that catalyze the uptake of sugars through facilitated diffusion. This family of transporters show conservation of 12 transmembrane helices as well as functionally significant amino acid, residues.
Synonyms:
solute carrier family 2 (facilitated glucose transporter), member 12
UniProt Protein Function:
GLUT12: an integral membrane facilitative glucose transporter. One of 13 members of the human equilibrative glucose transport protein family. Expressed in the heart, skeletal muscle, brown adipose tissue, and prostate.Protein type: Transporter, SLC family; Membrane protein, integral; Transporter; Membrane protein, multi-passChromosomal Location of Human Ortholog: 6q23.2Cellular Component: perinuclear region of cytoplasm; integral to membrane; plasma membrane; endomembrane systemMolecular Function: substrate-specific transmembrane transporter activityBiological Process: glucose transport; transmembrane transport
UniProt Protein Details:
NCBI Summary:
SLC2A12 belongs to a family of transporters that catalyze the uptake of sugars through facilitated diffusion (Rogers et al., 2002). This family of transporters show conservation of 12 transmembrane helices as well as functionally significant amino acid residues (Joost and Thorens, 2001 [PubMed 11780753]).[supplied by OMIM, Mar 2008]
