Description
Smox Antibody (PACO30012)
The Smox Antibody (PACO30012) is a high-quality polyclonal antibody designed for research involving the enzyme spermine oxidase (Smox). Spermine oxidase is a key player in polyamine metabolism, with implications in various cellular processes such as cell growth, differentiation, and apoptosis. This antibody, generated in rabbits, exhibits strong reactivity with human samples and has been validated for use in applications such as Western blotting. By specifically binding to the Smox enzyme, researchers can effectively detect and analyze its expression in different cell types.
This makes the Smox Antibody an excellent tool for studying polyamine metabolism and its role in conditions like cancer, neurodegenerative diseases, and inflammation.Understanding the function and regulation of Smox is essential for unraveling its contribution to disease pathogenesis and identifying potential therapeutic targets. With its reliability and specificity, the Smox Antibody is a valuable asset for researchers exploring the complex interplay of polyamine metabolism in health and disease.
| Antibody Name: | Smox Antibody (PACO30012) |
| Antibody SKU: | PACO30012 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:1000-1:5000 |
| Species Reactivity: | Mouse, Human |
| Immunogen: | Recombinant Mouse Spermine oxidase protein (1-555AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot All lanes: Smox antibody at 3µg/ml Lane 1: PC-3 whole cell lysate Lane 2: A549 whole cell lysate Lane 3: 293T whole cell lysate Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 62, 66, 27, 23, 28, 60, 57, 47, 61, 21 kDa Observed band size: 62 kDa . |
| Background: | Flavoenzyme which catalyzes the oxidation of spermine to spermidine. Can also use N(1)-acetylspermine and spermidine as substrates, with different affinity depending on the isoform (isozyme) and on the experimental conditions. Plays an important role in the regulation of polyamine intracellular concentration and has the potential to act as a determinant of cellular sensitivity to the antitumor polyamine analogs. May contribute to beta-alanine production via aldehyde dehydrogenase conversion of 3-amino-propanal. |
| Synonyms: | Spermine oxidase (EC 1.5.3.16) (Polyamine oxidase 1) (PAO-1) (PAOh1), Smox, Smo |
| UniProt Protein Function: | SMOX: Flavoenzyme which catalyzes the oxidation of spermine to spermidine. Can also use N(1)-acetylspermine and spermidine as substrates, with different affinity depending on the isoform (isozyme) and on the experimental conditions. Plays an important role in the regulation of polyamine intracellular concentration and has the potential to act as a determinant of cellular sensitivity to the antitumor polyamine analogs. May contribute to beta-alanine production via aldehyde dehydrogenase conversion of 3-amino-propanal. Belongs to the flavin monoamine oxidase family. 6 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Oxidoreductase; EC 1.5.3.16 Cellular Component: cytoplasm; nucleus Molecular Function:oxidoreductase activity; polyamine oxidase activity Biological Process: polyamine catabolic process; spermine catabolic process |
| UniProt Code: | Q99K82 |
| NCBI GenInfo Identifier: | 295389670 |
| NCBI Gene ID: | 228608 |
| NCBI Accession: | NP_001171304.1 |
| UniProt Secondary Accession: | Q99K82,Q70LA3, Q70LA4, Q70LA5, Q70LA7, Q70LA8, Q70LA9 A2ANQ8, A2ANQ9, A2ANR0, A2ANR1, A2ANR2, |
| UniProt Related Accession: | Q99K82 |
| Molecular Weight: | 63.9 kDa |
| NCBI Full Name: | spermine oxidase isoform a |
| NCBI Synonym Full Names: | spermine oxidase |
| NCBI Official Symbol: | Smox  |
| NCBI Official Synonym Symbols: | PAO; SMO; PAOh1; B130066H01Rik  |
| NCBI Protein Information: | spermine oxidase |
| UniProt Protein Name: | Spermine oxidase |
| UniProt Synonym Protein Names: | Polyamine oxidase 1; PAO-1; PAOh1 |
| Protein Family: | Spermine oxidase |
| UniProt Gene Name: | Smox  |
| UniProt Entry Name: | SMOX_MOUSE |
