The SPATA17 Antibody (PAC015064) is a valuable tool for researchers studying SPATA17, a gene associated with spermatogenesis and male fertility. This polyclonal antibody, produced in rabbits, has been validated for use in various types of experiments, including Western blot analysis. By targeting the SPATA17 protein, this antibody allows for the detection and analysis of SPATA17 in different cell types, making it an essential tool for studies in reproductive biology and infertility research.SPATA17, also known as SperMATagonia-associated protein 17, is crucial for the development and function of male germ cells.
Mutations in the SPATA17 gene have been linked to male infertility, making it a significant target for research in this field. By investigating the role of SPATA17 in spermatogenesis, researchers can gain insight into the underlying mechanisms of infertility and potentially develop new therapies to treat male reproductive disorders. This antibody provides a reliable way to study SPATA17 and advance our understanding of male fertility.
The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using PACO15064(SPATA17 Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: x200).
Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane: Human liver cancer tissue, Primary antibody: PACO15064(SPATA17 Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute.
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO15064(SPATA17 Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: x200).
Background:
Spata17 gene, which called MSRG11, by digital differential display of ESTs found only in testis. The deduced 292-amino acid, protein was considered to be a member of the family of calmodulin (CaM)-binding proteins because it contained 3 short CaM-binding motifs containing conserved ile and gln residues (IQ motif). Spata17 protein was most abundant in the cytoplasm of round spermatids and elongating spermatids within seminiferous tubules of the adult testis. Expression gradually decreased in the manipulated testis of animals that underwent experimental unilateral cryptorchidism. Transient transfection experiments with a Spata17 expression construct in cultured spermatogonia GC-1 cells indicated that Spata17 accelerated apoptosis in a dose-dependent manner.
Synonyms:
spermatogenesis associated 17
UniProt Protein Function:
SPATA17: Chromosomal Location of Human Ortholog: 1q41Cellular Component: cytoplasmMolecular Function: calmodulin binding
