The SPCS2 Polyclonal Antibody (PAC035458) is a valuable tool for researchers studying SPCS2, a key protein involved in cellular processes such as protein synthesis and quality control. This antibody, produced in rabbits, has high specificity for human samples and has been validated for Western blot applications. By binding to the SPCS2 protein, this antibody enables accurate detection and analysis in a variety of cell types, making it an essential reagent for studies in molecular biology and cell physiology.SPCS2, also known as signal peptidase complex subunit 2, is a critical component of the signal recognition particle pathway, which plays a crucial role in protein secretion and membrane protein integration.
Dysregulation of SPCS2 has been implicated in various diseases, including cancer and neurodegenerative disorders, highlighting its importance as a potential therapeutic target. Studying the function and regulation of SPCS2 is essential for unraveling the mechanisms underlying these diseases and developing targeted interventions for treatment.
Immunohistochemistry of paraffin-embedded human colon cancer using PACO35458 at dilution of 1:100.
Immunofluorescent analysis of Hela cells using PACO35458 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Immunohistochemistry of paraffin-embedded human testis tissue using PACO35458 at dilution of 1:100.
Background:
Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum.
Synonyms:
Signal peptidase complex subunit 2 (EC 3.4.-.-) (Microsomal signal peptidase 25 kDa subunit) (SPase 25 kDa subunit), SPCS2, KIAA0102 SPC25
UniProt Protein Function:
SPCS2: Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Belongs to the SPCS2 family.Protein type: EC 3.4.-.-; Protease; Membrane protein, multi-pass; Membrane protein, integralChromosomal Location of Human Ortholog: 11q13.4Cellular Component: endoplasmic reticulum membrane; integral to membrane; signal peptidase complexMolecular Function: peptidase activityBiological Process: protein targeting to ER; signal peptide processing
