The SPIC Polyclonal Antibody (PAC037934) is a valuable tool for researchers studying SPIC, a transcription factor involved in regulating immune responses. This antibody, raised in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. By binding to the SPIC protein, this antibody allows for the detection and analysis of SPIC in various cell types, making it ideal for studies in immunology and cancer research.SPIC, also known as Spi-C, plays a crucial role in immune system modulation by regulating gene expression in immune cells. Its involvement in immune response regulation makes it a key target for research into diseases such as cancer, autoimmune disorders, and inflammatory conditions.
Understanding the function of SPIC is essential for the development of potential therapies that target immune responses in these disease contexts.Overall, the SPIC Polyclonal Antibody offers researchers a reliable tool for investigating the role of SPIC in immune regulation and disease pathogenesis. Its specificity and sensitivity make it an essential component in studies aimed at advancing our understanding of immune system function and developing effective therapeutic strategies.
Immunohistochemistry of paraffin-embedded human breast cancer using PACO37934 at dilution of 1:100.
Western Blot. Positive WB detected in: Mouse heart tissue, Mouse liver tissue. All lanes: SPIC antibody at 3.4µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 30 kDa. Observed band size: 30 kDa.
Immunohistochemistry of paraffin-embedded human small intestine tissue using PACO37934 at dilution of 1:100.
Background:
Controls the development of red pulp macrophages required for red blood cells recycling and iron homeostasis. Transcription factor that binds to the PU-box, a purine-rich DNA sequence (5'-GAGGA[AT]-3') that can act as a lymphoid-specific enhancer. Regulates VCAM1 gene expression (By similarity).
Synonyms:
Transcription factor Spi-C, SPIC
UniProt Protein Function:
SPIC: Controls the development of red pulp macrophages required for red blood cells recycling and iron homeostasis. Transcription factor that binds to the PU-box, a purine-rich DNA sequence (5'-GAGGA[AT]-3') that can act as a lymphoid-specific enhancer. Regulates VCAM1 gene expression. Belongs to the ETS family.
UniProt Protein Details:
Protein type:DNA-binding
Chromosomal Location of Human Ortholog: 12q23.2
Cellular Component: nucleus
Biological Process: cell differentiation; regulation of transcription from RNA polymerase II promoter
NCBI Summary:
The protein encoded by this gene regulates the development of red pulp macrophages, which are necessary for iron homeostasis and the recycling of red blood cells. [provided by RefSeq, Aug 2016]
