The SSH3 Polyclonal Antibody (PACO23466) is a valuable tool for researchers studying the SSH3 protein, which is involved in cell signaling pathways related to cancer and immune regulation. This antibody, generated in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications.SSH3, also known as suppressor of speechless homolog 3, is a key player in cell migration, invasion, and metastasis in cancer cells. Additionally, SSH3 has been implicated in regulating immune responses by modulating T cell activation and proliferation.
The SSH3 Polyclonal Antibody binds specifically to the SSH3 protein, enabling accurate detection and analysis in a variety of cell types.Research involving SSH3 is essential for understanding its role in cancer progression and immune regulation, making this antibody an ideal choice for studies in oncology, immunology, and cell biology. By targeting SSH3, researchers can uncover new insights into potential therapeutic targets for cancer and immune-related disorders.
Synthesized peptide derived from internal of human SSH3.
Form:
Liquid
Storage Buffer:
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Western blot analysis of extracts from HuvEc cells, using SSH3 antibody.
Immunohistochemistry analysis of paraffin-embedded human lung carcinoma tissue using SSH3 antibody.
Background:
Protein phosphatase which may play a role in the regulation of actin filament dynamics. Can dephosphorylate and activate the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly By similarity.
Synonyms:
Protein phosphatase Slingshot homolog 3; SSH-3L; hSSH-3L;
UniProt Protein Function:
SSH3: a protein phosphatase which may play a role in the regulation of actin filament dynamics. Can dephosphorylate and activate the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Does not bind to, or colocalize with, filamentous actin. Five alternatively spliced isoforms have been described.Protein type: Cytoskeletal; EC 3.1.3.16; Protein phosphatase, dual-specificity; Phosphatase; Motility/polarity/chemotaxis; EC 3.1.3.48; Protein phosphatase, Ser/Thr (non-receptor)Chromosomal Location of Human Ortholog: 11q13.2Cellular Component: cytoplasmMolecular Function: actin bindingBiological Process: regulation of actin polymerization and/or depolymerization; regulation of axonogenesis
UniProt Protein Details:
NCBI Summary:
The ADF (actin-depolymerizing factor)/cofilin family (see MIM 601442) is composed of stimulus-responsive mediators of actin dynamics. ADF/cofilin proteins are inactivated by kinases such as LIM domain kinase-1 (LIMK1; MIM 601329). The SSH family appears to play a role in actin dynamics by reactivating ADF/cofilin proteins in vivo (Niwa et al., 2002 [PubMed 11832213]).[supplied by OMIM, Mar 2008]
