The ST18 Polyclonal Antibody (PAC017159) is a valuable tool for researchers studying ST18, a transcription factor involved in various cellular processes, including cell proliferation and differentiation. Raised in rabbits, this antibody is highly specific to human ST18 protein and has been validated for use in Western blot applications. By binding to ST18, this antibody enables accurate detection and analysis in a variety of cell types, making it an essential component for studies in molecular biology and cancer research.
Known for its role in regulating gene expression and cell cycle progression, ST18 is a key player in the development and progression of various diseases, including cancer. By understanding the function and regulation of ST18, researchers can gain insights into potential therapeutic targets for cancer treatment and other disorders. The ST18 Polyclonal Antibody offers a reliable tool for investigating the intricate mechanisms involving ST18, ultimately advancing our knowledge of its biological significance.
Antibody Name:
ST18 Antibody (PACO17159)
Antibody SKU:
PACO17159
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:1000-1:5000, IHC:1:40-1:150
Species Reactivity:
Human, Mouse, Rat
Immunogen:
Fusion protein of human ST18
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using PACO17159(ST18 Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: x200).
Background:
ST18 (suppression of tumorigenicity 18), also known as ZNF387 ((zinc finger protein 387), is a 1,047 amino acid, nuclear protein that is expressed at low levels in heart, liver, kidney, skeletal muscle, pancreas, testis, ovary and prostate. Containing six C2HC-type zinc fingers and an SMC domain, ST18 is a repressor protein that binds to DNA sequences containing a specific bipartite element. ST18 is considered a transcription factor that represses basal transcription activity from target promoters and Inhibits colony formation in cultured breast cancer cells.
Synonyms:
suppression of tumorigenicity 18, zinc finger
UniProt Protein Function:
ST18: Repressor that binds to DNA sequences containing a bipartite element consisting of a direct repeat of the sequence 5'-AAAGTTT-3' separated by 2-9 nucleotides. Represses basal transcription activity from target promoters. Inhibits colony formation in cultured breast cancer cells.Chromosomal Location of Human Ortholog: 8q11.23Cellular Component: nucleusMolecular Function: DNA binding; zinc ion binding; transcription factor activityBiological Process: regulation of transcription, DNA-dependent; transcription, DNA-dependent
