Human SERTAD1 Recombinant Protein (RPPB4650)
- SKU:
- RPPB4650
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q9UHV2
Description
| Product Name: | Human SERTAD1 Recombinant Protein |
| Product Code: | RPPB4650 |
| Size: | 10µg |
| Species: | Human |
| Target: | SERTAD1 |
| Synonyms: | SERTA domain-containing protein 1, CDK4-binding protein p34SEI1, SEI-1, Transcriptional regulator interacting with the PHD-bromodomain 1, TRIP-Br1, SERTAD1, SEI1. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile filtered colorless solution. |
| Formulation: | SERTAD1 protein solution (0.5mg/ml) containing 20mM Tris-HCl buffer (pH8.0), 10% glycerol and 1mM DTT. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 85% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSHMLSKGL KRKREEEEEK EPLAVDSWWL DPGHTAVAQA PPAVASSSLF DLSVLKLHHS LQQSEPDLRH LVLVVNTLRR IQASMAPAAA LPPVPSPPAA PSVADNLLAS SDAALSASMA SLLEDLSHIE GLSQAPQPLA DEGPPGRSIG GAAPSLGALD LLGPATGCLL DDGLEGLFED IDTSMYDNEL WAPASEGLKP GPEDGPGKEE APELDEAELD YLMDVLVGTQ ALERPPGPGR |
SERTA domain-containing protein (SERTAD1) functions with E2F-responsive promoters to integrate signals provided by PHD- and/or bromodomain-containing transcription factors. SERTAD1 stimulates E2F-1/DP-1 transcriptional activity. SERTAD1 reduces the activity of cyclin D1/CDK4 resistant to the inhibitory effects of p16(INK4a). In addition, SERTAD1 interacts with the PHD-bromodomain of TIF1, TRIM28/TIF1B and p300/CBP. Furthermore, SERTAD1 binds to DP1 and interacts with CDK4.
SERTAD1 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 260 amino acids (1-236 a.a) and having a molecular mass of 27.3kDa (Molecular weight on SDS-PAGE will appear higher).SERTAD1 is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | SERTAD1: Acts at E2F-responsive promoters to integrate signals provided by PHD- and/or bromodomain-containing transcription factors. Stimulates E2F-1/DP-1 transcriptional activity. Renders the activity of cyclin D1/CDK4 resistant to the inhibitory effects of p16(INK4a). |
| UniProt Protein Details: | Protein type:Cell cycle regulation; Transcription regulation Chromosomal Location of Human Ortholog: 19q13.1-q13.2 Molecular Function:protein binding Biological Process: transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; positive regulation of cell proliferation; regulation of cyclin-dependent protein kinase activity |
| UniProt Code: | Q9UHV2 |
| NCBI GenInfo Identifier: | 153792060 |
| NCBI Gene ID: | 29950 |
| NCBI Accession: | NP_037508.2 |
| UniProt Secondary Accession: | Q9UHV2,Q9BUE7, |
| UniProt Related Accession: | Q9UHV2 |
| Molecular Weight: | 24,704 Da |
| NCBI Full Name: | SERTA domain-containing protein 1 |
| NCBI Synonym Full Names: | SERTA domain containing 1 |
| NCBI Official Symbol: | SERTAD1�� |
| NCBI Official Synonym Symbols: | SEI1; TRIP-Br1�� |
| NCBI Protein Information: | SERTA domain-containing protein 1; CDK4-binding protein p34SEI; CDK4-binding protein p34SEI1; SEI-1; transcriptional regulator interacting with the PHD-bromodomain 1 |
| UniProt Protein Name: | SERTA domain-containing protein 1 |
| UniProt Synonym Protein Names: | CDK4-binding protein p34SEI1; SEI-1; Transcriptional regulator interacting with the PHD-bromodomain 1; TRIP-Br1 |
| UniProt Gene Name: | SERTAD1�� |
| UniProt Entry Name: | SRTD1_HUMAN |
