The TAPBP Polyclonal Antibody (CAB13357) is a valuable tool for researchers studying the TAPBP protein, which plays a crucial role in antigen presentation and immune response regulation. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to the TAPBP protein, this antibody enables accurate detection and analysis in a variety of cell types, making it ideal for investigations in immunology and cancer research.TAPBP, also known as TAP binding protein, is essential for the proper functioning of the major histocompatibility complex (MHC) class I antigen presentation pathway.
By assisting in the loading of peptides onto MHC class I molecules, TAPBP contributes to the recognition of infected or abnormal cells by the immune system. Research on TAPBP is important for understanding immune surveillance and responses to pathogens, as well as for developing therapies targeting antigen presentation in diseases such as cancer and autoimmune disorders. This antibody facilitates the study of TAPBP's role in these processes, providing valuable insights for the development of new treatments and immunotherapies.
Product Name:
TAPBP Rabbit Polyclonal Antibody
SKU:
CAB13357
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 30-260 of human TAPBP (NP_757345.2).
Endoplasmic reticulum membrane, Single-pass type I membrane protein.
Calculated MW:
48kDa
Observed MW:
48kDa
This gene encodes a transmembrane glycoprotein which mediates interaction between newly assembled major histocompatibility complex (MHC) class I molecules and the transporter associated with antigen processing (TAP), which is required for the transport of antigenic peptides across the endoplasmic reticulum membrane. This interaction is essential for optimal peptide loading on the MHC class I molecule. Up to four complexes of MHC class I and this protein may be bound to a single TAP molecule. This protein contains a C-terminal double-lysine motif (KKKAE) known to maintain membrane proteins in the endoplasmic reticulum. This gene lies within the major histocompatibility complex on chromosome 6. Alternative splicing results in three transcript variants encoding different isoforms.
Purification Method:
Affinity purification
Gene ID:
6892
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using TAPBP antibody (CAB13357) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.
