The TGF beta Receptor I (TGFBR1) Antibody (CAB0708) is a high-quality antibody developed for reliable detection and analysis of target proteins. This antibody, generated in rabbits, demonstrates high specificity and sensitivity in detecting TGFBR1 in human samples, making it an excellent choice for Western blot applications. By targeting the TGFBR1 protein, researchers can explore its role in various cellular processes, including cell growth, differentiation, and immune response modulation.TGFBR1, a type I receptor for the transforming growth factor beta (TGF-β) family of ligands, is involved in regulating cell proliferation, differentiation, and apoptosis. Dysregulation of TGFBR1 signaling has been implicated in numerous diseases, including cancer, fibrosis, and autoimmune disorders.
This antibody is validated for use in WB, ELISA applications and has demonstrated reactivity against Human, Mouse, Rat samples.
Product Name:
TGF beta Receptor I (TGFBR1) Antibody
SKU:
CAB0708
Size:
20μL, 100μL
Reactivity:
Human, Mouse, Rat
Conjugate:
Unconjugated
Immunogen:
Synthetic peptide. This information is considered to be commercially sensitive.
Sequence:
CCNQ DHCN KIEL PTTV KSSP GLGP VELA AVIA GPVC FVCI SLML MVYI CHNR TVIH HRVP NEED PSLD RPFI SEGT TLKD LIYD MTTS GSGS GLPL LVQR T
Tested Applications:
WBELISA
Recommended Dilution:
WB
1:500 - 1:5000
ELISA
Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Cell Junction, Cell Membrane, Single-Pass Type I Membrane Protein, Tight Junction.
Calculated MW:
56kDa
Observed MW:
56kDa
The protein encoded by this gene forms a heteromeric complex with type II TGF-beta receptors when bound to TGF-beta, transducing the TGF-beta signal from the cell surface to the cytoplasm. The encoded protein is a serine/threonine protein kinase. Mutations in this gene have been associated with Loeys-Dietz aortic aneurysm syndrome (LDAS). Multiple transcript variants encoding different isoforms have been found for this gene.
Purification Method
Affinity purification
Gene ID
7046
RRID
AB_2757355
Buffer Information
Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol, preserved with proclin300 or sodium azide, pH 7.3.
Western blot analysis of lysates from 293T cells, using TGF beta Receptor I (TGFBR1) Rabbit pAb (CAB0708) at 1:1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Exposure time: 180s.
Western blot analysis of various lysates using TGF beta Receptor I (TGFBR1) Rabbit pAb (CAB0708) at 1:1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (AbGn00021). Exposure time: 180s.
