The THG1L Polyclonal Antibody (PAC012739) is a valuable tool for researchers studying THG1L, a protein involved in tRNA editing and mitochondrial function. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to the THG1L protein, this antibody enables precise detection and analysis in a variety of cell types, making it an ideal choice for investigations in molecular biology and mitochondrial research.THG1L is an essential protein involved in maintaining tRNA integrity and functionality, particularly in mitochondria where tRNA editing is critical for protein synthesis.
Understanding the role of THG1L is key to unraveling the mechanisms behind mitochondrial disorders and potential therapeutic targets for mitochondrial diseases. Research into THG1L may provide insights into how tRNA editing influences mitochondrial function and cellular health, with implications for conditions related to mitochondrial dysfunction.
tRNA-histidine guanylyltransferase 1-like (S. cerevisiae);THG1L;FLJ11601;FLJ20546;ICF45 ;
UniProt Protein Function:
ICF45: Adds a GMP to the 5'-end of tRNA(His) after transcription and RNase P cleavage. This step is essential for proper recognition of the tRNA and for the fidelity of protein synthesis. Belongs to the tRNA(His) guanylyltransferase family.Protein type: EC 2.7.7.79; Cell cycle regulation; Mitochondrial; TransferaseChromosomal Location of Human Ortholog: 5q33.3Cellular Component: mitochondrion; cytoplasmMolecular Function: identical protein binding; tRNA guanylyltransferase activity; GTP binding; magnesium ion binding; ATP binding; tRNA bindingBiological Process: tRNA processing; tRNA modification; protein homotetramerization
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene is a mitochondrial protein that is induced by high levels of glucose and is associated with diabetic nephropathy. The encoded protein appears to increase mitochondrial biogenesis, which could lead to renal fibrosis. Another function of this protein is that of a guanyltransferase, adding GMP to the 5' end of tRNA(His). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015]
