The Troponin I2 (TNNI2) Monoclonal Antibody (CAB4740) is a high-quality antibody developed for reliable detection and analysis of target proteins. This antibody, produced in rabbits, is highly specific and reactive with human samples, making it ideal for research in cardiology and muscle physiology.Troponin I is a key regulatory protein in the troponin complex, which controls the contraction of striated muscle tissue. Elevated levels of Troponin I in the bloodstream are a sensitive and specific marker of myocardial injury, making it an important diagnostic tool for detecting heart attacks and other cardiac conditions.The TNni2 Rabbit Monoclonal Antibody binds specifically to Troponin I, allowing for accurate detection and quantification in various samples and tissues.
This antibody is validated for use in WB, ELISA, IF-P applications and has demonstrated reactivity against Mouse, Rat samples.
Product Name:
Troponin I2 (TNNI2) Monoclonal Antibody
SKU:
CAB4740
Size:
20μL, 100μL
Reactivity:
Mouse, Rat
Clone Number:
ARC1114
Conjugate:
Unconjugated
Immunogen:
Synthetic peptide. This information is considered to be commercially sensitive.
This gene encodes a fast-twitch skeletal muscle protein, a member of the troponin I gene family, and a component of the troponin complex including troponin T, troponin C and troponin I subunits. The troponin complex, along with tropomyosin, is responsible for the calcium-dependent regulation of striated muscle contraction. Mouse studies show that this component is also present in vascular smooth muscle and may play a role in regulation of smooth muscle function. In addition to muscle tissues, this protein is found in corneal epithelium, cartilage where it is an inhibitor of angiogenesis to inhibit tumor growth and metastasis, and mammary gland where it functions as a co-activator of estrogen receptor-related receptor alpha. This protein also suppresses tumor growth in human ovarian carcinoma. Mutations in this gene cause myopathy and distal arthrogryposis type 2B. Alternatively spliced transcript variants have been found for this gene.
Purification Method
Affinity purification
Gene ID
7136
RRID
AB_2863337
Buffer Information
Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol and 0.05% BSA, preserved with proclin300 or sodium azide, pH 7.3.
Western blot analysis of various lysates using Troponin I2 (Troponin I2 (TNNI2)) Rabbit mAb (CAB4740) at 1:1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Exposure time: 30s.
Immunofluorescence analysis of paraffin-embedded mouse bone marrow using Troponin I2 (Troponin I2 (TNNI2)) Rabbit mAb (CAB4740) at dilution of 1:100 (40x lens). Secondary antibody: Cy3-conjugated Goat anti-Rabbit IgG (H+L) (CABS007) at 1:500 dilution. Blue: DAPI for nuclear staining.
