The TREML2 Polyclonal Antibody (PACO36538) is a valuable tool for researchers studying TREML2, a transmembrane protein with potential roles in immune function and inflammation. This antibody, raised in rabbits, is highly specific for detecting TREML2 in human samples and has been validated for use in Western blot applications.TREML2, also known as triggering receptor expressed on myeloid cells-like 2, is thought to be involved in modulating immune responses, particularly in the context of inflammatory processes. Its expression pattern and function make it an intriguing target for investigation in immunology and related fields. By using the TREML2 Polyclonal Antibody, researchers can gain insights into the expression levels and localization of TREML2 in various cell types, aiding in the understanding of its potential roles in health and disease.
Given the potential implications of TREML2 in immune regulation and inflammation, research with this antibody could contribute to the development of new strategies for treating conditions such as autoimmune disorders, chronic inflammatory diseases, and cancer. As the scientific community continues to uncover the functions of TREML2, the TREML2 Polyclonal Antibody will be a valuable asset for furthering knowledge in this important area of research.
Antibody Name:
TREML2 Antibody (PACO36538)
Antibody SKU:
PACO36538
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:20-1:200
Species Reactivity:
Human
Immunogen:
Recombinant Human Trem-like transcript 2 protein (19-268AA)
Immunohistochemistry of paraffin-embedded human colon cancer using PACO36538 at dilution of 1:100.
Immunohistochemistry of paraffin-embedded human adrenal gland tissue using PACO36538 at dilution of 1:100.
Background:
Cell surface receptor that may play a role in the innate and adaptive immune response. Acts as a counter-receptor for CD276 and interaction with CD276 on T-cells enhances T-cell activation.
Synonyms:
Trem-like transcript 2 protein (TLT-2) (Triggering receptor expressed on myeloid cells-like protein 2), TREML2, C6orf76 TLT2
UniProt Protein Function:
TREML2: Cell surface receptor that may play a role in the innate and adaptive immune response. Acts as a counter-receptor for CD276 and interaction with CD276 on T-cells enhances T-cell activation.Protein type: Membrane protein, integralChromosomal Location of Human Ortholog: 6p21.1Cellular Component: cell surface; integral to membrane; plasma membraneMolecular Function: protein binding; receptor activityBiological Process: T cell activation
UniProt Protein Details:
NCBI Summary:
TREML2 is located in a gene cluster on chromosome 6 with the single Ig variable (IgV) domain activating receptors TREM1 (MIM 605085) and TREM2 (MIM 605086), but it has distinct structural and functional properties (Allcock et al., 2003 [PubMed 12645956]).[supplied by OMIM, Mar 2008]
