The TUBA1B Monoclonal Antibody (PAC021560) is designed for researchers studying TUBA1B, a key component of microtubules essential for various cellular processes. This antibody, produced in rabbits, exhibits high specificity and sensitivity towards human samples, making it suitable for Western blot applications. By binding to TUBA1B, this antibody allows for precise detection and analysis in a variety of cell types, making it a valuable tool for investigations in cell biology, neurology, and cancer research.TUBA1B is a crucial protein involved in cell division, intracellular transport, and cell shape maintenance.
Dysregulation of TUBA1B has been linked to neurodegenerative diseases, cancer progression, and developmental disorders. Research on TUBA1B is therefore important for understanding the mechanisms underlying these conditions and for developing potential therapeutic strategies targeting microtubule dynamics.Overall, the TUBA1B Monoclonal Antibody is a reliable tool for researchers investigating the role of TUBA1B in various cellular processes and diseases, with the potential to contribute to advancements in medical research and drug development.
Antibody Name:
TUBA1B Antibody (PACO21560)
Antibody SKU:
PACO21560
Size:
100ul
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:2000-1:10000, WB:1:500-1:1000
Species Reactivity:
Human, Mouse, Rat
Immunogen:
Peptide sequence around aa.437-441(V-D-S-V-E) derived from Human alpha-Tubulin.
Form:
Liquid
Storage Buffer:
Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method:
Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Western blot analysis of extracts from Hela and HT29 cells using alpha-Tubulin Antibody .
Background:
Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the β chain and one at a non-exchangeable site on the a-chain. Cowan N.J., Dobner P., Fuchs E.V., Cleveland D.W.Mol. Cell. Biol. 3:1738-1745(1983)
Synonyms:
K-ALPHA-1
UniProt Protein Function:
TUBA1B: Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain. Dimer of alpha and beta chains. Belongs to the tubulin family.
UniProt Protein Details:
Protein type:Cytoskeletal; Motility/polarity/chemotaxis
Molecular Function:GTPase activity; protein binding; GTP binding; structural constituent of cytoskeleton; ubiquitin protein ligase binding; double-stranded RNA binding; structural molecule activity
Biological Process: protein polymerization; 'de novo' posttranslational protein folding; cellular protein metabolic process; protein folding; cell division; cytoskeleton-dependent intracellular transport; microtubule cytoskeleton organization and biogenesis; microtubule-based process
