The UFD1L Monoclonal Antibody (CAB20977) is a high-quality antibody developed for reliable detection and analysis of target proteins. This antibody, raised in rabbits, shows high reactivity with human samples and is specifically validated for use in Western blot applications.UFD1L is a key player in maintaining cellular homeostasis by facilitating the degradation of misfolded or damaged proteins, thereby preventing the accumulation of toxic protein aggregates. Dysregulation of UFD1L has been linked to various diseases, including neurodegenerative disorders and cancer.
This antibody is validated for use in WB, ELISA applications and has demonstrated reactivity against Human, Rat samples.
Product Name:
UFD1L Monoclonal Antibody
SKU:
CAB20977
Size:
20μL, 100μL
Reactivity:
Human, Rat
Clone Number:
ARC2969
Conjugate:
Unconjugated
Immunogen:
Synthetic peptide. This information is considered to be commercially sensitive.
Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Synonyms:
UFD1L
Positive Sample:
HepG2, MCF7, Rat testis
Cellular Localization:
Cytoplasm, Nucleus, Cytosol.
Calculated MW:
35kDa
Observed MW:
40kDa
The protein encoded by this gene forms a complex with two other proteins, nuclear protein localization-4 and valosin-containing protein, and this complex is necessary for the degradation of ubiquitinated proteins. In addition, this complex controls the disassembly of the mitotic spindle and the formation of a closed nuclear envelope after mitosis. Mutations in this gene have been associated with Catch 22 syndrome as well as cardiac and craniofacial defects. Alternative splicing results in multiple transcript variants encoding different isoforms. A related pseudogene has been identified on chromosome 18.
Purification Method
Affinity purification
Gene ID
7353
Buffer Information
Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol and 0.05% BSA, preserved with proclin300 or sodium azide, pH 7.3.
Western blot analysis of various lysates using UFD1L Rabbit mAb (CAB20977) at 1:500 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Exposure time: 30s.
