The Acetyl-H2B (FS) K12 Polyclonal Antibody (PACO04630) is a valuable tool for research involving post-translational modifications of histone proteins, specifically acetylation of lysine 12 on histone H2B. This antibody, raised in rabbits, exhibits high reactivity with human samples and is validated for use in various applications, including Western blot and immunofluorescence.Histone acetylation plays a crucial role in chromatin remodeling and gene expression regulation, with abnormalities in histone acetylation associated with various diseases, including cancer and neurological disorders. The Acetyl-H2B (FS) K12 antibody enables precise detection and analysis of acetylated histone H2B, providing researchers with a tool to investigate the role of histone acetylation in cellular processes and disease development.
By understanding the specific modifications of histone proteins, researchers can gain insights into epigenetic regulation and potential therapeutic targets for diseases influenced by chromatin remodeling. The Acetyl-H2B (FS) K12 Polyclonal Antibody is a valuable asset for studies in epigenetics, cancer biology, and drug development aimed at targeting histone modifications.
Antibody Name:
Acetyl-H2BFS (K12) Antibody
Antibody SKU:
PACO04630
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB, IHC, IF
Recommended Dilutions:
WB:1:500-1:2000, IHC:1:100-1:300, IF:1:200-1:1000
Species Reactivity:
Human, Mouse, Monkey
Immunogen:
synthesized peptide derived from human Histone H2B around the acetylation site of K12.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Synonyms:
H2BFS; Histone H2B type F-S; Histone H2B.s; H2B/s
UniProt Protein Function:
H2BFS: a core component of the nucleoosome. The nucleosome, a basic organizational unit of chromosomal DNA, is octrameric, consisting of two molecules each of histones H2B, H2A, H3, H4. The octamer wraps approximately 147 bp of DNA. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.Protein type: DNA-bindingChromosomal Location of Human Ortholog: 21q22.3Cellular Component: cytoplasm; extracellular space; nucleoplasm; nucleusMolecular Function: DNA binding; protein heterodimerization activityBiological Process: antibacterial humoral response; defense response to Gram-positive bacterium; innate immune response in mucosa; nucleosome assembly; substantia nigra development
