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Anti-ADM Antibody (CAB8659)

SKU:
CAB8659
Product Type:
Antibody
Applications:
WB
Reactivity:
Human
Mouse
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Neuroscience
$167 - $503
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Description

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Antibody Name:Anti-ADM Antibody
Antibody SKU:CAB8659
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Mouse
Host Species:Rabbit
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 50-150 of human ADM (NP_001115.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Mouse
Positive Samples:Mouse kidney
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 50-150 of human ADM (NP_001115.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:SSYP TGLA DVKA GPAQ TLIR PQDM KGAS RSPE DSSP DAAR IRVK RYRQ SMNN FQGL RSFG CRFG TCTV QKLA HQIY QFTD KDKD NVAP RSKI SPQG YGRR R
Gene ID:133
Uniprot:P35318
Cellular Location:Secreted
Calculated MW:20kDa
Observed MW:20kDa
Synonyms:ADM, AM, PAMP
Background:The protein encoded by this gene is a preprohormone which is cleaved to form two biologically active peptides, adrenomedullin and proadrenomedullin N-terminal 20 peptide. Adrenomedullin is a 52 aa peptide with several functions, including vasodilation, regulation of hormone secretion, promotion of angiogenesis, and antimicrobial activity. The antimicrobial activity is antibacterial, as the peptide has been shown to kill E. coli and S. aureus at low concentration.
UniProt Protein Function:ADM: AM and PAMP are potent hypotensive and vasodilatator agents. Numerous actions have been reported most related to the physiologic control of fluid and electrolyte homeostasis. In the kidney, am is diuretic and natriuretic, and both am and pamp inhibit aldosterone secretion by direct adrenal actions. In pituitary gland, both peptides at physiologically relevant doses inhibit basal ACTH secretion. Both peptides appear to act in brain and pituitary gland to facilitate the loss of plasma volume, actions which complement their hypotensive effects in blood vessels. Belongs to the adrenomedullin family.
UniProt Protein Details:

Protein type:Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 11p15.4

Cellular Component: cytoplasm; extracellular region; extracellular space

Molecular Function:protein binding; receptor binding

Biological Process: antibacterial humoral response; antifungal humoral response; blood circulation; cAMP biosynthetic process; cell-cell signaling; defense response to Gram-negative bacterium; defense response to Gram-positive bacterium; G-protein coupled receptor internalization; negative regulation of vasoconstriction; positive regulation of cAMP biosynthetic process; progesterone biosynthetic process; receptor internalization; response to yeast; signal transduction; vasculogenesis

NCBI Summary:The protein encoded by this gene is a preprohormone which is cleaved to form two biologically active peptides, adrenomedullin and proadrenomedullin N-terminal 20 peptide. Adrenomedullin is a 52 aa peptide with several functions, including vasodilation, regulation of hormone secretion, promotion of angiogenesis, and antimicrobial activity. The antimicrobial activity is antibacterial, as the peptide has been shown to kill E. coli and S. aureus at low concentration. [provided by RefSeq, Aug 2014]
UniProt Code:P35318
NCBI GenInfo Identifier:461474
NCBI Gene ID:133
NCBI Accession:P35318.1
UniProt Secondary Accession:P35318,Q6FGW2, B2R793, D3DQV3,
UniProt Related Accession:P35318
Molecular Weight:20,420 Da
NCBI Full Name:ADM
NCBI Synonym Full Names:adrenomedullin
NCBI Official Symbol:ADM  
NCBI Official Synonym Symbols:AM; PAMP  
NCBI Protein Information:ADM
UniProt Protein Name:ADM
UniProt Synonym Protein Names:Adrenomedullin; AM
Protein Family:ADM
UniProt Gene Name:ADM  
UniProt Entry Name:ADML_HUMAN
Anti-ADM Polyclonal Antibody (CAB8659)Western blot analysis of extracts of Mouse kidney, using ADM antibody (CAB8659) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 15s.

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