Description
| Product Name: | Anti-Human IFNAR1 (Anifrolumab) |
| Product Code: | IVMB0397 |
| Size: | 5 mg |
| Clone: | MEDI-546 |
| Antibody Type: | Monoclonal Antibody |
| Synonyms: | Anifrolumab, MEDI-546, IFNAR1, IFNAR, Interferon α/β Receptor 1, 1326232-46-5 |
| Isotype: | Human IgG1κ |
| Reactivity: | Human |
| Expression Host: | HEK-293 Cells |
| FC Effector Activity: | Active |
| Product Concentration: | ≥ 5.0 mg/ml |
| Purity: | ≥95% by SDS Page⋅≥95% monomer by analytical SEC |
| Formulation: | This biosimilar antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.2 - 7.4 with no carrier protein, potassium, calcium or preservatives added. Due to inherent biochemical properties of antibodies, certain products may be prone to precipitation over time. Precipitation may be removed by aseptic centrifugation and/or filtration. |
| Endotoxin Level: | ≤ 1.0 EU/mg as determined by the LAL method |
| Specificity: | This non-therapeutic biosimilar antibody uses the same variable region sequence as the therapeutic antibody Anifrolumab. This product is for research use only. Anifrolumab activity is directed against Human IFNAR1. |
| Antigen Distribution: | IFNAR1 is a plasma membrane protein widely expressed on most nucleated cells that undergoes endocytosis when activated. |
| Immunogen: | Human IFNAR1 |
| Product Preparation: | Recombinant biosimilar antibodies are manufactured in an animal free facility using only in vitro protein free cell culture techniques and are purified by a multi-step process including the use of protein A or G to assure extremely low levels of endotoxins, leachable protein A or aggregates. |
| Pathogen Testing: | To protect mouse colonies from infection by pathogens and to assure that experimental preclinical data is not affected by such pathogens, all of Leinco’s recombinant biosimilar antibodies are tested and guaranteed to be negative for all pathogens in the IDEXX IMPACT I Mouse Profile. |
| Target: | IFNAR1 |
| Storage and Handling: | Functional grade biosimilar antibodies may be stored sterile as received at 2-8°C for up to one month. For longer term storage, aseptically aliquot in working volumes without diluting and store at -80°C. Avoid Repeated Freeze Thaw Cycles. |
