The Biotinylated Anti-B7-2 Antibody (HDLA046) is a valuable tool for researchers studying immune responses and immune regulation. This antibody, generated through immunization of animals, specifically targets the B7-2 protein, also known as CD86, which is a critical co-stimulatory molecule involved in T cell activation.The B7-2 antibody is highly reactive with human samples, making it suitable for various research applications such as Western blotting and immunohistochemistry. By binding to the B7-2 protein, researchers can detect and analyze its expression in different cell types, providing insights into the mechanisms underlying immune activation and regulation.
Given the role of B7-2 in modulating immune responses, this antibody is particularly valuable for studies in immunology, cancer research, and autoimmune disorders. Understanding the expression and function of B7-2 can lead to the development of novel therapies targeting immune checkpoints for the treatment of various diseases.Overall, the Biotinylated Anti-B7-2 Antibody (HDLA046) is a reliable tool for researchers seeking to investigate the role of B7-2 in immune regulation and its potential implications for disease pathogenesis and therapy development.
SKU:
HDLA046
Size:
100 µg
Clonality:
Monoclonal
Clone:
DM84
Synonyms:
CD86, B7-2, B70, CD28LG2, LAB72, MGC34413
Applications:
ELISA, Flow Cyt
Recommended Dilution:
ELISA 1:5000-10000; Flow Cyt 1:100
Host Species:
Rabbit
Isotype:
Rabbit IgG
Reactivity:
Human
Purification Method:
Purified from cell culture supernatant by affinity chromatography
Formulation:
Powder
Buffer:
1XPBS
Storage:
Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing).Lyophilized antibodies are shipped at ambient temperature.
Usage:
Research use only
Background:
This gene encodes a type I membrane protein that is a member of the immunoglobulin superfamily. This protein is expressed by antigen-presenting cells, and it is the ligand for two proteins at the cell surface of T cells, CD28 antigen and cytotoxic T-lymphocyte-associated protein 4. Binding of this protein with CD28 antigen is a costimulatory signal for activation of the T-cell. Binding of this protein with cytotoxic T-lymphocyte-associated protein 4 negatively regulates T-cell activation and diminishes the immune response. Alternative splicing results in several transcript variants encoding different isoforms.
