The Biotinylated Anti-B7-H2 Antibody (HDLA059) is a valuable tool for research involving the B7-H2 protein, a critical regulator of immune response and T cell activation. This antibody, produced in-house at Assay Genie, is specifically designed for use in various applications such as immunohistochemistry, flow cytometry, and ELISA.B7-H2, also known as ICOSL, is a co-stimulatory molecule expressed on antigen-presenting cells that interacts with its receptor, ICOS, on T cells to promote T cell activation and effector function. This interaction is crucial for regulating immune responses and maintaining immune homeostasis. The Biotinylated Anti-B7-H2 Antibody (HDLA059) enables researchers to detect and analyze B7-H2 expression in various cell types and tissues, making it ideal for studies in immunology, autoimmunity, and cancer research.
By understanding the role of B7-H2 in immune regulation and T cell function, researchers can gain insights into the development of novel immunotherapies and treatment strategies for diseases such as cancer, autoimmune disorders, and inflammatory conditions. The Biotinylated Anti-B7-H2 Antibody (HDLA059) provides a reliable and specific tool for investigating the function of B7-H2 and its potential as a therapeutic target in various disease settings.
Purified from cell culture supernatant by affinity chromatography
Formulation:
Powder
Buffer:
1XPBS
Storage:
Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing).Lyophilized antibodies are shipped at ambient temperature.
Usage:
Research use only
Background:
Inducible co-stimulator ligand (ICOSL), also known as B7-H2, is a member of the B7 family of co-stimulatory molecules related to B7-1 and B7-2.The protein is the ligand for the T-cell-specific cell surface receptor ICOS. Acts as a costimulatory signal for T-cell proliferation and cytokine secretion; induces also B-cell proliferation and differentiation into plasma cells. Could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co-stimulating memory T-cell function.
