The Biotinylated Anti-B7-H2 Antibody (HDLA060) is a powerful tool for research involving B7-H2, a cell surface protein involved in regulating immune responses. This antibody, produced using cutting-edge biotinylation technology, is highly specific for B7-H2 and is validated for use in various assays, including immunofluorescence and flow cytometry.B7-H2, also known as inducible co-stimulator ligand (ICOSL), plays a crucial role in T cell activation and immune regulation. By binding to its receptor, ICOS, B7-H2 enhances T cell responses and promotes the production of cytokines involved in inflammation and immune reactions.
Understanding the function of B7-H2 is essential for unraveling the complexities of immune activation and developing targeted therapies for conditions such as autoimmune diseases and cancer.The Biotinylated Anti-B7-H2 Antibody (HDLA060) provides researchers with a reliable tool for studying B7-H2 expression and function in various cell types and tissues. Its high specificity and sensitivity make it an invaluable reagent for investigating the role of B7-H2 in immune responses and developing novel therapeutic strategies for immune-related disorders.
Purified from cell culture supernatant by affinity chromatography
Formulation:
Powder
Buffer:
1XPBS
Storage:
Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing).Lyophilized antibodies are shipped at ambient temperature.
Usage:
Research use only
Background:
Inducible co-stimulator ligand (ICOSL), also known as B7-H2, is a member of the B7 family of co-stimulatory molecules related to B7-1 and B7-2.The protein is the ligand for the T-cell-specific cell surface receptor ICOS. Acts as a costimulatory signal for T-cell proliferation and cytokine secretion; induces also B-cell proliferation and differentiation into plasma cells. Could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co-stimulating memory T-cell function.
