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Key Features

CD73 monoclonal antibody (PE) (AGIM0056)

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SKU AGIM0056
Product Type Antibody
Antibody Type Monoclonal Antibody
Reactivity Human
Host Species Mouse
Isotype IgG1
Clone AD2
Conjugation PE
Applications FC
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Description

system_update_altDatasheet
Product Name:CD73 monoclonal antibody (PE)
Product Code:AGIM0056
Size:500 µL
Reactivity:Human
Clone:AD2
Applications:Flow Cytometry
Conjugate:PE
Isotype:IgG1
Host Species:Mouse
Storage:Store at 4°C. Do not freeze. Avoid prolonged exposure to light.
Uniprot:P21589
Background:CD73 (ecto-5'-nucleotidase) is a 70 kDa glycoprotein anchored to the extracellular leaflet of the plasma membrane by GPI. This ecto-enzyme catalyzes dephosphorylation of AMP to adenosine. CD73 is expressed in various types of cells, such as epithelial, muscle, and endothelial cells, neutrophils, lymphocytesand fibroblasts. Inflammatory mediators support CD73 expression and its enzymatic activity, leading to the release of adenosine, which modulates inflammation through adenosine receptors. CD73 is expressed in a variety of lymphomas and leukemias, including ALL and CLL, whereas immunodeficient patients usually express low levels of this protein.
UniProt Protein Function:NT5E: Hydrolyzes extracellular nucleotides into membrane permeable nucleosides. Homodimer; disulfide-linked. Belongs to the 5'-nucleotidase family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:EC 3.1.3.5; Membrane protein, integral; Nucleotide Metabolism - pyrimidine; Nucleotide Metabolism - purine; Phosphatase (non-protein); Membrane protein, GPI anchor; Cofactor and Vitamin Metabolism - nicotinate and nicotinamide

Chromosomal Location of Human Ortholog: 6q14-q21

Cellular Component: cell surface; membrane; cytoplasm; plasma membrane

Molecular Function:5'-nucleotidase activity; metal ion binding; nucleotide binding

Biological Process: pyrimidine nucleoside catabolic process; dephosphorylation; pyrimidine base metabolic process; nucleobase, nucleoside and nucleotide metabolic process; adenosine biosynthetic process; negative regulation of inflammatory response; purine nucleotide catabolic process; DNA metabolic process; purine base metabolic process; AMP catabolic process

Disease: Calcification Of Joints And Arteries

NCBI Summary:The protein encoded by this gene is a plasma membrane protein that catalyzes the conversion of extracellular nucleotides to membrane-permeable nucleosides. The encoded protein is used as a determinant of lymphocyte differentiation. Defects in this gene can lead to the calcification of joints and arteries. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2011]
UniProt Code:P21589
NCBI GenInfo Identifier:112825
NCBI Gene ID:4907
NCBI Accession:P21589.1
UniProt Related Accession:P21589
Molecular Weight:
NCBI Full Name:5'-nucleotidase
NCBI Synonym Full Names:5'-nucleotidase ecto
NCBI Official Symbol:NT5E  
NCBI Official Synonym Symbols:NT; eN; NT5; NTE; eNT; CD73; E5NT; CALJA  
NCBI Protein Information:5'-nucleotidase
UniProt Protein Name:5'-nucleotidase
UniProt Synonym Protein Names:Ecto-5'-nucleotidase; CD_antigen: CD73
UniProt Gene Name:NT5E  
UniProt Entry Name:5NTD_HUMAN

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