The CES2 Polyclonal Antibody (CAB13640) is a valuable tool for researchers studying Carboxylesterase 2 (CES2), an enzyme involved in the metabolism of various drugs and xenobiotics. This antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for use in applications such as Western blotting.CES2 plays a crucial role in drug metabolism, particularly in the hydrolysis of ester and amide bonds in various pharmaceutical compounds. Its activity has implications in drug efficacy, toxicity, and drug-drug interactions, making it a key target for pharmacological research.
By utilizing the CES2 Polyclonal Antibody, researchers can detect and analyze CES2 protein levels in different cell types, shedding light on its role in drug metabolism and potential therapeutic implications. This antibody is a valuable tool for drug development studies, pharmacogenomics research, and investigations into drug metabolism pathways.
Product Name:
CES2 Rabbit Polyclonal Antibody
SKU:
CAB13640
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 310-410 of human CES2 (NP_003860.3).
This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. The protein encoded by this gene is the major intestinal enzyme and functions in intestine drug clearance. Alternatively spliced transcript variants have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
8824
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using CES2 antibody (CAB13640) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.
