The Claudin-10 Polyclonal Antibody (CAB9853) is a valuable tool for researchers studying Claudin-10, a protein that plays a crucial role in tight junction formation and epithelial barrier function. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in various applications, including Western blot and immunohistochemistry.Claudin-10 is a key player in maintaining the integrity of epithelial cell barriers, which are important for controlling the passage of molecules and ions between cells. Dysregulation of Claudin-10 has been implicated in various diseases, including inflammatory bowel disease and certain types of cancer.
By using the Claudin-10 Polyclonal Antibody, researchers can study the expression and localization of Claudin-10 in different cell types and tissues, providing insights into its role in health and disease.With its high specificity and sensitivity, the Claudin-10 Polyclonal Antibody is an essential tool for researchers investigating the function and regulation of Claudin-10 in physiological and pathological conditions. Its versatility and reliability make it an invaluable asset in studies focused on epithelial barrier function, tight junctions, and related disorders.
Product Name:
CLDN10 Rabbit Polyclonal Antibody
SKU:
CAB9853
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human CLDN10 (NP_008915.1).
This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. The expression level of this gene is associated with recurrence of primary hepatocellular carcinoma. Six alternatively spliced transcript variants encoding different isoforms have been reported, but the transcript sequences of some variants are not determined.
Purification Method:
Affinity purification
Gene ID:
9071
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of rat lung, using CLDN10 antibody (CAB9853) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 60s.
