The CRELD2 Polyclonal Antibody (PACO16073) is a valuable tool for researchers studying the role of CRELD2 in various biological processes. This antibody, raised in rabbits, is highly specific to CRELD2 and is validated for use in a range of applications, including Western blot and immunofluorescence.CRELD2, also known as cysteine-rich with EGF-like domains 2, is a protein involved in cell adhesion and signaling pathways. It has been implicated in development, cell migration, and cell differentiation, making it a protein of interest in developmental biology and cancer research.
The CRELD2 Polyclonal Antibody enables researchers to detect and analyze CRELD2 expression in various cell types, providing insights into its function and potential therapeutic applications.With its high specificity and versatility in applications, the CRELD2 Polyclonal Antibody is a valuable tool for researchers seeking to unravel the complex mechanisms underlying CRELD2 function in health and disease.
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO16073(CRELD2 Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: x200).
Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Human fetal liver tissue, Primary antibody: PACO16073(CRELD2 Antibody) at dilution 1/421, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2 minutes.
The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using PACO16073(CRELD2 Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: x200).
Background:
CRELD2 (cysteine-rich with EGF-like domains 2) is a 353 amino acid, protein that is ubiquitously expressed and contains two FU domains and two EGF-like domains. Localized to the endoplasmic reticulum and secreted into the cell, CRELD2 interacts with AChR 4, possibly regulating its transport. Human CRELD2 shares 69% amino acid, identity with its mouse counterpart, suggesting a conserved role between species. Multiple isoforms of CRELD2 exist due to alternative splicing events. The gene encoding CRELD2 maps to human chromosome 22, which houses over 500 genes and is the second smallest human chromosome.
Synonyms:
cysteine-rich with EGF-like domains 2
UniProt Protein Function:
CRELD2: May regulate transport of alpha4-beta2 neuronal acetylcholine receptor. Belongs to the CRELD family. 6 isoforms of the human protein are produced by alternative splicing.Protein type: Secreted, signal peptide; SecretedChromosomal Location of Human Ortholog: 22q13.33Molecular Function: protein binding
