Description
DP-2 Transcription Factor Activity Assay
The DP-2 Transcription Factor Activity Assay is a versatile and reliable tool for studying the activity of transcription factors in various biological samples. This assay kit offers high sensitivity and specificity, allowing for accurate and reproducible results in serum, plasma, and cell culture supernatants.Transcription factors play a vital role in regulating gene expression and are involved in a wide range of biological processes, including cell growth, differentiation, and development. By measuring the activity of these factors, researchers can gain valuable insights into gene regulation and potential therapeutic targets.
The DP-2 Transcription Factor Activity Assay is suitable for a variety of research applications, particularly in the fields of cancer, cardiovascular diseases, and neurodegenerative disorders. With its user-friendly format and robust performance, this assay kit is an essential tool for investigating transcription factor function and identifying potential pathways for targeted treatments.
| Product Name: | DP-2 Transcription Factor Activity Assay |
| Product Code: | TFAB00091 |
| Target: | DP-2 |
| Synonyms: | E2F dimerization partner 2 |
| Reactivity: | Human, Mouse, Rat |
| Sample Types: | Nuclear or cell lysates |
The Assay Genie DP-2 transcription factor activity assay allows for the detection and qualitative analysis of endogenous levels of activated transcription factors in a variety of nuclear and cell lysates
Assay Genie ELISA kits are designed to significantly reduce experiment time and ensure sensitivity and flexibility for high-throughput screening.
| Assay Time: | 4.5 hours |
| Detection Method: | Colorimetric 450 nm |
| Size: | 12 x 8-Well Microstrips |
| Storage: | 4°C for 6 months |
| UniProt Protein Function: | TFDP2: Can stimulate E2F-dependent transcription. Binds DNA cooperatively with E2F family members through the E2 recognition site, 5'-TTTC[CG]CGC-3', found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DP2/E2F complex functions in the control of cell-cycle progression from G1 to S phase. The E2F1/DP complex appears to mediate both cell proliferation and apoptosis. Belongs to the E2F/DP family. 6 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:DNA-binding Chromosomal Location of Human Ortholog: 3q23 Cellular Component: nucleoplasm; transcription factor complex Molecular Function:protein domain specific binding; DNA binding; transcription cofactor activity; transcription factor binding; transcription factor activity Biological Process: transcription initiation from RNA polymerase II promoter; Notch signaling pathway; transcription, DNA-dependent; transforming growth factor beta receptor signaling pathway; positive regulation of transcription from RNA polymerase II promoter; gene expression; mitotic cell cycle |
| NCBI Summary: | The gene is a member of the transcription factor DP family. The encoded protein forms heterodimers with the E2F transcription factors resulting in transcriptional activation of cell cycle regulated genes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010] |
| UniProt Code: | Q14188 |
| NCBI GenInfo Identifier: | 8039810 |
| NCBI Gene ID: | 7029 |
| NCBI Accession: | Q14188.2 |
| UniProt Related Accession: | Q14188 |
| Molecular Weight: | |
| NCBI Full Name: | Transcription factor Dp-2 |
| NCBI Synonym Full Names: | transcription factor Dp-2 |
| NCBI Official Symbol: | TFDP2Â Â |
| NCBI Official Synonym Symbols: | DP2Â Â |
| NCBI Protein Information: | transcription factor Dp-2 |
| UniProt Protein Name: | Transcription factor Dp-2 |
| UniProt Synonym Protein Names: | E2F dimerization partner 2 |
| UniProt Gene Name: | TFDP2Â Â |
| UniProt Entry Name: | TFDP2_HUMAN |
