The DYNLT1 Polyclonal Antibody (CAB4150) is a valuable tool for research involving DYNLT1, a protein that plays a crucial role in various cellular processes, such as intracellular transport and cell division. This antibody, generated in rabbits, displays high reactivity with human samples and is specifically validated for use in Western blot applications. By targeting the DYNLT1 protein, this antibody enables researchers to detect and analyze the protein in different cell types, making it suitable for studies in cell biology and molecular biology.
DYNLT1, also known as Tctex1, is a component of the dynein motor complex and is involved in the retrograde transport of cargo along microtubules. Its importance in cellular transport mechanisms makes it a promising target for research in areas such as neurobiology, developmental biology, and cancer biology. Understanding the function and regulation of DYNLT1 can provide valuable insights into how disruptions in intracellular transport contribute to disease pathogenesis and could lead to the development of novel therapeutic strategies.
Product Name:
DYNLT1 Rabbit Polyclonal Antibody
SKU:
CAB4150
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-113 of human DYNLT1 (NP_006510.1).
This gene encodes a component of the motor complex, cytoplasmic dynein, which transports cellular cargo along microtubules in the cell. The encoded protein regulates the length of primary cilia which are sensory organelles found on the surface of cells. The protein encoded by this gene interacts with viral proteins, like the minor capsid protein L2 of human papillomavirus, and is required for dynein-mediated delivery of the viral nucleic acid to the host nucleus. This protein interacts with oncogenic nucleoporins to disrupt gene regulation and cause leukemic transformation. Pseudogenes of this gene are present on chromosomes 4 and 17. Alternative splicing results in multiple transcript variants encoding different isoforms.
Purification Method:
Affinity purification
Gene ID:
6993
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using DYNLT1 antibody (CAB4150) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 60s.
