Description
Anti-SNCG Antibody (CAB2524)
The Gamma-Synuclein Polyclonal Antibody (CAB2524) is a versatile tool for researchers studying the gamma-synuclein protein, which has been implicated in various neurodegenerative disorders, including Parkinson's disease. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications.Gamma-synuclein is a member of the synuclein family of proteins and is primarily expressed in neuronal cells, where it plays a role in neuronal plasticity and neurotransmitter release. Dysregulation of gamma-synuclein has been linked to the pathogenesis of Parkinson's disease and other neurodegenerative conditions, making it a key target for investigation.
By using the Gamma-Synuclein Polyclonal Antibody, researchers can detect and analyze gamma-synuclein expression in various cell types, providing valuable insights into its function and potential therapeutic implications. This antibody is an invaluable tool for studies in neuroscience, neurology, and neurodegenerative disease research, helping to further our understanding of the role of gamma-synuclein in health and disease.
| Antibody Name: | Anti-SNCG Antibody |
| Antibody SKU: | CAB2524 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC IF |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-127 of human SNCG (NP_003078.2). |
| Application: | WB IHC IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse |
| Positive Samples: | HT-29, Mouse brain |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-127 of human SNCG (NP_003078.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MDVF KKGF SIAK EGVV GAVE KTKQ GVTE AAEK TKEG VMYV GAKT KENV VQSV TSVA EKTK EQAN AVSE AVVS SVNT VATK TVEE AENI AVTS GVVR KEDL RPSA PQQE GEAS KEKE EVAE EAQS GGD |
| Gene ID: | 6623 |
| Uniprot: | O76070 |
| Cellular Location: | Cytoplasm, centrosome, cytoskeleton, microtubule organizing center, perinuclear region, spindle |
| Calculated MW: | 13kDa |
| Observed MW: | 13kDa |
| Synonyms: | SNCG, BCSG1, SR |
| Background: | This gene encodes a member of the synuclein family of proteins which are believed to be involved in the pathogenesis of neurodegenerative diseases. Mutations in this gene have also been associated with breast tumor development. |
| UniProt Protein Function: | SNCG: a member of the synuclein family of proteins which are believed to be involved in the pathogenesis of neurodegenerative diseases. May be involved in modulating axonal architecture during development and in the adult. Plays a role in neurofilament network integrity. High levels have been identified in advanced breast carcinomas. |
| UniProt Protein Details: | Protein type:Adaptor/scaffold Chromosomal Location of Human Ortholog: 10q23.2-q23.3 Cellular Component: cell soma; perinuclear region of cytoplasm; cytoplasm; plasma membrane; microtubule organizing center; spindle; nerve terminal Molecular Function:beta-tubulin binding; alpha-tubulin binding Biological Process: response to drug; synaptic transmission; adult locomotory behavior; protein secretion; regulation of neurotransmitter secretion; synapse organization and biogenesis; response to cocaine; regulation of dopamine secretion |
| NCBI Summary: | This gene encodes a member of the synuclein family of proteins which are believed to be involved in the pathogenesis of neurodegenerative diseases. Mutations in this gene have also been associated with breast tumor development. [provided by RefSeq, Jan 2010] |
| UniProt Code: | O76070 |
| NCBI GenInfo Identifier: | 90110074 |
| NCBI Gene ID: | 6623 |
| NCBI Accession: | O76070.2 |
| UniProt Secondary Accession: | O76070,O15104, Q96P61, |
| UniProt Related Accession: | O76070 |
| Molecular Weight: | 127 |
| NCBI Full Name: | Gamma-synuclein |
| NCBI Synonym Full Names: | synuclein, gamma (breast cancer-specific protein 1) |
| NCBI Official Symbol: | SNCGÂ Â |
| NCBI Official Synonym Symbols: | SR; BCSG1Â Â |
| NCBI Protein Information: | gamma-synuclein; persyn; synoretin; breast cancer-specific gene 1 protein |
| UniProt Protein Name: | Gamma-synuclein |
| UniProt Synonym Protein Names: | Breast cancer-specific gene 1 protein; Persyn; Synoretin; SR |
| Protein Family: | Gamma-synuclein |
| UniProt Gene Name: | SNCGÂ Â |
| UniProt Entry Name: | SYUG_HUMAN |
 | Western blot analysis of extracts of various cell lines, using SNCG antibody (CAB2524) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 60s. |
 | Immunohistochemistry of paraffin-embedded human thyroid cancer using SNCG antibody (CAB2524) at dilution of 1:200 (40x lens). |
 | Immunofluorescence analysis of U2OS cells using SNCG antibody (CAB2524). Blue: DAPI for nuclear staining. |
Related Products
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