Recombinant Human ACE2 Protein (Fc Tag) (RPES0028)
Angiotensin-Converting Enzyme 2 (ACE-2) is an integral membrane protein and a zinc metalloprotease of the ACE family, the ACE family includes somatic and germinal ACE. ACE-2 cleaves angiotensins I and II as a carboxypeptidase, ACE-2 converts angiotensin I to angiotensin 1-9, and angiotensin II to angiotensin 1-7. ACE-2 is also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. ACE-2 can be high expressed in testis, kidney and heart, in colon, small intestine and ovary at moderate levels. Captopril and lisinopril as the classical ACE inhibitor don't inhibit ACE-2 activity. ACE-2 may play an important role in regulating the heart function.
Immobilized Human ACE-2-Fc(Cat#RPES0028) at 2ug/ml (100 uL/well) can bind 2019-nCoV S Protein RBD-SD1-mFc(Cat#RPES0012). The ED50 of SARS-Cov-2 S Protein RBD-mFc(Cat#RPES0012) is 15.5 ug/ml .
Formulation:
Supplied as a 0.2 uM filtered solution of 20mM Tris-HCl, 300mM NaCl, 1mM ZnCl2, 10% Glycerol, pH 7.4.
Storage:
Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8? for 2-7 days. Aliquots of reconstituted samples are stable at < -20? for 3 months.
Shipping:
This product is provided as lyophilized powder which is shipped with ice packs.
