Human ACE2 Recombinant Protein (RPES2538)

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Recombinant Protein
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ELISA Kit Technical Manual

Recombinant Human ACE2 Protein (His Tag)

Background:Angiotensin-Converting Enzyme 2 (ACE-2) is an integral membrane protein and a zinc metalloprotease of the ACE family, the ACE family includes somatic and germinal ACE. ACE-2 cleaves angiotensins I and II as a carboxypeptidase, ACE-2 converts angiotensin I to angiotensin 1-9, and angiotensin II to angiotensin 1-7. ACE-2 is also able to hydrolyze apelin3 and dynorphin3 with high efficiency. ACE-2 can be high expressed in testis, kidney and heart, in colon, small intestine and ovary at moderate levels. Captopril and lisinopril as the classical ACE inhibitor don’t inhibit ACE-2 activity. ACE-2 may play an important role in regulating the heart function.
Name:Recombinant Human ACE2 Protein (His Tag)
Assay Genie SKU:RPES2538
Synonyms:Angiotensin-Converting Enzyme 2; ACE-Related Carboxypeptidase; Angiotensin-Converting Enzyme Homolog; ACEH; Metalloprotease MPROT15; ACE2
Expression host:Human Cells
Mol Mass:84.6 kDa
AP Mol Mass:103 kDa
Purity:> 95 % as determined by reducing SDS-PAGE.
Endotoxin:< 1.0 EU per µg as determined by the LAL method.
Storage:Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Shipping:This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs.Upon receipt; store it immediately at<-20°C.
Formulation:Supplied as a 0.2 um filtered solution of 20mM Tris-HCl, 150mM NaCl, 0.1mM ZnCl2, 10% Glycerol, pH 7.5.
Reconstitution:Please refer to the printed manual for detailed information.
UniProt Protein Function:ACE2: Carboxypeptidase which converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator. Also able to hydrolyze apelin- 13 and dynorphin3 with high efficiency. May be an important regulator of heart function. In case of human coronaviruses SARS and HCoV-NL63 infections, serve as functional receptor for the spike glycoprotein of both coronaviruses. Interacts with ITGB1. Interacts with SARS-CoV and HCoV- NL63 spike glycoprotein. Up-regulated in failing heart. Expressed in endothelial cells from small and large arteries, and in arterial smooth muscle cells. Expressed in lung alveolar epithelial cells, enterocytes of the small intestine, Leydig cells and Sertoli cells. Expressed in heart, kidney, testis, and gastrointestinal system. Activated by chloride and fluoride, but not bromide. Inhibited by MLN-4760, cFP_Leu, and EDTA, but not by the ACE inhibitors linosipril, captopril and enalaprilat. Belongs to the peptidase M2 family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Membrane protein, integral; EC; Protease

Chromosomal Location of Human Ortholog: Xp22

Cellular Component: cell surface; extracellular region; extracellular space; lipid raft; plasma membrane

Molecular Function:carboxypeptidase activity; endopeptidase activity; glycoprotein binding; metallocarboxypeptidase activity; metallopeptidase activity; peptidyl-dipeptidase activity; protein binding; viral receptor activity; zinc ion binding

Biological Process: angiotensin catabolic process in blood; angiotensin maturation; angiotensin mediated drinking behavior; entry of virus into host cell; receptor biosynthetic process; regulation of cell proliferation; regulation of cytokine production; regulation of inflammatory response; regulation of systemic arterial blood pressure by renin-angiotensin; regulation of vasoconstriction; regulation of vasodilation; virion attachment, binding of host cell surface receptor

NCBI Summary:The protein encoded by this gene belongs to the angiotensin-converting enzyme family of dipeptidyl carboxydipeptidases and has considerable homology to human angiotensin 1 converting enzyme. This secreted protein catalyzes the cleavage of angiotensin I into angiotensin 1-9, and angiotensin II into the vasodilator angiotensin 1-7. The organ- and cell-specific expression of this gene suggests that it may play a role in the regulation of cardiovascular and renal function, as well as fertility. In addition, the encoded protein is a functional receptor for the spike glycoprotein of the human coronaviruses SARS and HCoV-NL63. [provided by RefSeq, Jul 2008]
UniProt Code:Q9BYF1
NCBI GenInfo Identifier:71658783
NCBI Gene ID:59272
NCBI Accession:Q9BYF1.2
UniProt Secondary Accession:Q9BYF1,Q6UWP0, Q86WT0, Q9NRA7, Q9UFZ6, C7ECU1,
UniProt Related Accession:Q9BYF1
Molecular Weight:63,912 Da
NCBI Full Name:Angiotensin-converting enzyme 2
NCBI Synonym Full Names:angiotensin I converting enzyme 2
NCBI Official Symbol:ACE2
NCBI Official Synonym Symbols:ACEH
NCBI Protein Information:angiotensin-converting enzyme 2
UniProt Protein Name:Angiotensin-converting enzyme 2
UniProt Synonym Protein Names:ACE-related carboxypeptidase; Angiotensin-converting enzyme homolog; ACEH
Protein Family:Angiotensin-converting enzyme
UniProt Gene Name:ACE2
UniProt Entry Name:ACE2_HUMAN