Human AGR2 Recombinant Protein (RPPB2714)
- SKU:
- RPPB2714
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- O95994
Description
| Product Name: | Human AGR2 Recombinant Protein |
| Product Code: | RPPB2714 |
| Size: | 20µg |
| Species: | Human |
| Target: | AGR2 |
| Synonyms: | Anterior gradient protein 2 homolog, Secreted cement gland protein XAG-2 homolog, AG-2, hAG-2, HPC8, AGR2, AG2, GOB-4, HAG-2, XAG-2. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile filtered colorless solution. |
| Formulation: | The protein contains 20mM Tris-HCl pH 8.0, 1mM DTT, 1mM EDTA and 10% Glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 95.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSMRDT TVKPGAKKDT KDSRPKLPQT LSRGWGDQLI WTQTYEEALY KSKTSNKPLM IIHHLDECPH SQALKKVFAE NKEIQKLAEQ FVLLNLVYET TDKHLSPDGQ YVPRIMFVDP SLTVRADITG RYSNRLYAYE PADTALLLDN MKKALKLLKT EL |
AGR2 (Anterior gradient 2 homolog) is the human orthologue of the secreted Xenopus laevis Anterior Gradient protein (XAG-2). This is a small, possibly secreted molecule of yet weakly defined functions that is widely expressed in human tissues. Expression of AGR2 shows a positive correlation with expression of estrogen receptor in breast carcinoma and a negative correlation with expression of EGF receptor.
AGR2 Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 191 amino acids (21-175 a.a.) and having a molecular mass of 21.9 kDa. AGR2 protein is fused to a 36 amino acid His-Tag at N-terminus and purified by standard chromatography.
| UniProt Protein Function: | AGR2: Required for MUC2 post-transcriptional synthesis and secretion. May play a role in the production of mucus by intestinal cells. Proto-oncogene that may play a role in cell migration, cell differentiation and cell growth. Interacts with LYPD3 and DAG1 (alphaDAG1). Interacts with MUC2; disulfide-linked. Expressed strongly in trachea, lung, stomach, colon, prostate and small intestine. Expressed weakly in pituitary gland, salivary gland, mammary gland, bladder, appendix, ovary, fetal lung, uterus, pancreas, kidney, fetal kidney, testis, placenta, thyroid gland and in estrogen receptor (ER)-positive breast cancer cell lines. Belongs to the AGR family. |
| UniProt Protein Details: | Protein type:Secreted; Oncoprotein; Secreted, signal peptide Chromosomal Location of Human Ortholog: 7p21.3 Cellular Component: endoplasmic reticulum; extracellular space Molecular Function:epidermal growth factor receptor binding; protein binding; protein homodimerization activity Biological Process: digestive tract morphogenesis; positive regulation of developmental growth; positive regulation of epidermal growth factor receptor signaling pathway |
| UniProt Code: | O95994 |
| NCBI GenInfo Identifier: | 67462105 |
| NCBI Gene ID: | 10551 |
| NCBI Accession: | O95994.1 |
| UniProt Related Accession: | O95994 |
| Molecular Weight: | 19,979 Da |
| NCBI Full Name: | Anterior gradient protein 2 homolog |
| NCBI Synonym Full Names: | anterior gradient 2, protein disulphide isomerase family member |
| NCBI Official Symbol: | AGR2�� |
| NCBI Official Synonym Symbols: | AG2; GOB-4; HAG-2; XAG-2; PDIA17; HEL-S-116�� |
| NCBI Protein Information: | anterior gradient protein 2 homolog |
| UniProt Protein Name: | Anterior gradient protein 2 homolog |
| UniProt Synonym Protein Names: | HPC8; Secreted cement gland protein XAG-2 homolog |
| Protein Family: | Anterior gradient protein |
| UniProt Gene Name: | AGR2�� |
| UniProt Entry Name: | AGR2_HUMAN |
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