Human C1D Recombinant Protein (RPPB2937)
- SKU:
- RPPB2937
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q13901
Description
| Product Name: | Human C1D Recombinant Protein |
| Product Code: | RPPB2937 |
| Size: | 10µg |
| Species: | Human |
| Target: | C1D |
| Synonyms: | hC1D, LRP1, SUN-CoR, SUNCOR, Nuclear nucleic acid-binding protein C1D, C1D. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered clear solution. |
| Formulation: | The C1D solution (0.5mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.2M NaCl, 50% glycerol and 2mM DTT. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 85% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMAGEEIN EDYPVEIHEY LSAFENSIGA VDEMLKTMMS VSRNELLQKL DPLEQAKVDL VSAYTLNSMF WVYLATQGVN PKEHPVKQEL ERIRVYMNRV KEITDKKKAG KLDRGAASRF VKNALWEPKS KNASKVANKG KSKS |
C1D s which regulates TRAX/Translin complex formation takes part in the recruitment of the RNA exosome complex to pre-rRNA to mediate the 3'-5' end processing of the 5.8S rRNA. C1D which activates PRKDC in the presence of linear DNA and supercoiled DNA also induces apoptosis in a p53/TP53 dependent manner.
C1D Human Recombinant produced in E. coli is a single polypeptide chain containing 164 amino acids (1-141) and having a molecular mass of 18.4kDa. C1D is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | C1D: Plays a role in the recruitment of the RNA exosome complex to pre-rRNA to mediate the 3'-5' end processing of the 5.8S rRNA; this function may include MPHOSPH6. Can activate PRKDC not only in the presence of linear DNA but also in the presence of supercoiled DNA. Can induce apoptosis in a p53/TP53 dependent manner. May regulate the TRAX/TSN complex formation. Potentiates transcriptional repression by NR1D1 and THRB. Belongs to the C1D family. |
| UniProt Protein Details: | Protein type:Nucleolus; DNA-binding; Transcription, coactivator/corepressor; Nuclear receptor co-regulator Chromosomal Location of Human Ortholog: 2p13-p12 Cellular Component: transcriptional repressor complex; cytoplasm; nucleolus; nucleus; nuclear exosome (RNase complex) Molecular Function:ligand-dependent nuclear receptor binding; protein binding; DNA binding; RNA binding; transcription corepressor activity Biological Process: maturation of 5.8S rRNA; transcription, DNA-dependent; apoptosis; negative regulation of transcription, DNA-dependent |
| NCBI Summary: | The protein encoded by this gene is a DNA binding and apoptosis-inducing protein and is localized in the nucleus. It is also a Rac3-interacting protein which acts as a corepressor for the thyroid hormone receptor. This protein is thought to regulate TRAX/Translin complex formation. Alternate splicing results in multiple transcript variants that encode the same protein. Multiple pseudogenes of this gene are found on chromosome 10.[provided by RefSeq, Jun 2010] |
| UniProt Code: | Q13901 |
| NCBI GenInfo Identifier: | 74754472 |
| NCBI Gene ID: | 10438 |
| NCBI Accession: | Q13901.1 |
| UniProt Secondary Accession: | Q13901,Q05D64, A8K336, D6W5F8, |
| UniProt Related Accession: | Q13901 |
| Molecular Weight: | 141 |
| NCBI Full Name: | Nuclear nucleic acid-binding protein C1D |
| NCBI Synonym Full Names: | C1D nuclear receptor corepressor |
| NCBI Official Symbol: | C1D�� |
| NCBI Official Synonym Symbols: | LRP1; hC1D; Rrp47; SUNCOR; SUN-CoR�� |
| NCBI Protein Information: | nuclear nucleic acid-binding protein C1D; C1D DNA-binding protein; nuclear DNA-binding protein; C1D nuclear receptor co-repressor; small unique nuclear receptor corepressor; small unique nuclear receptor co-repressor |
| UniProt Protein Name: | Nuclear nucleic acid-binding protein C1D |
| Protein Family: | Nuclear nucleic acid-binding protein |
| UniProt Gene Name: | C1D�� |
| UniProt Entry Name: | C1D_HUMAN |
