Human CCNG1 Recombinant Protein (RPPB3000)
- SKU:
- RPPB3000
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P51959
- Research Area:
- Enzymes
Description
| Product Name: | Human CCNG1 Recombinant Protein |
| Product Code: | RPPB3000 |
| Size: | 10µg |
| Species: | Human |
| Target: | CCNG1 |
| Synonyms: | Cyclin-G1, Cyclin-G, CCNG1, CCNG, CYCG1. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered clear colorless solution. |
| Formulation: | CCNG1 protein solution (0.25mg/ml) containing 20mM Tris-HCl buffer (pH8.0), 50% glycerol, 0.2M NaCl and 5mM DTT. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 85% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MIEVLTTTDS QKLLHQLNAL LEQESRCQPK VCGLRLIESA HDNGLRMTAR LRDFEVKDLL SLTQFFGFDT ETFSLAVNLL DRFLSKMKVQ PKHLGCVGLS CFYLAVKSIE EERNVPLATD LIRISQYRFT VSDLMRMEKI VLEKVCWKVK ATTAFQFLQL YYSLLQENLP LERRNSINFE RLEAQLKACH CRIIFSKAKP SVLALSIIAL EIQAQKCVEL TEGIECLQKH SKINGRDLTF WQELVSKCLT EYSSNKCSKP NVQKLKWIVS GRTARQLKHS YYRITHLPTI PEMVP |
Cyclin-G1 (CCNG1) belongs to the cyclin family and contains the cyclin box. CCNG1 may have a part in growth regulation and is associated with G2/M phase arrest in response to DNA damage. CCNG1 may be an intermediate by which p53 mediates its role as an inhibitor of cellular proliferation. The CCNG1 protein lacks the protein destabilizing (PEST) sequence which is present in other family members.
CCNG1 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 315 amino acids (1-295 a.a.) and having a molecular mass of 36.2kDa. CCNG1 is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | CCNG1: May play a role in growth regulation. Is associated with G2/M phase arrest in response to DNA damage. May be an intermediate by which p53 mediates its role as an inhibitor of cellular proliferation. Belongs to the cyclin family. Cyclin G subfamily. |
| UniProt Protein Details: | Protein type:Cell cycle regulation Chromosomal Location of Human Ortholog: 5q32-q34 Cellular Component: nucleoplasm Molecular Function:protein binding Biological Process: regulation of cyclin-dependent protein kinase activity |
| NCBI Summary: | The eukaryotic cell cycle is governed by cyclin-dependent protein kinases (CDKs) whose activities are regulated by cyclins and CDK inhibitors. The protein encoded by this gene is a member of the cyclin family and contains the cyclin box. The encoded protein lacks the protein destabilizing (PEST) sequence that is present in other family members. Transcriptional activation of this gene can be induced by tumor protein p53. Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P51959 |
| NCBI GenInfo Identifier: | 2506334 |
| NCBI Gene ID: | 900 |
| NCBI Accession: | P51959.2 |
| UniProt Secondary Accession: | P51959,Q15757, Q96L32, B2R7B2, B4DLW7, D3DQK7, |
| UniProt Related Accession: | P51959 |
| Molecular Weight: | 18,769 Da |
| NCBI Full Name: | Cyclin-G1 |
| NCBI Synonym Full Names: | cyclin G1 |
| NCBI Official Symbol: | CCNG1�� |
| NCBI Official Synonym Symbols: | CCNG�� |
| NCBI Protein Information: | cyclin-G1 |
| UniProt Protein Name: | Cyclin-G1 |
| Protein Family: | Cyclin |
| UniProt Gene Name: | CCNG1�� |
| UniProt Entry Name: | CCNG1_HUMAN |
