Human CD160 Recombinant Protein (RPPB3107)
- SKU:
- RPPB3107
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- O95971
- Research Area:
- CD Antigens
Description
| Product Name: | Human CD160 Recombinant Protein |
| Product Code: | RPPB3107 |
| Size: | 5µg |
| Species: | Human |
| Target: | CD160 |
| Synonyms: | CD160 Molecule, CD160 Antigen, Natural Killer Cell Receptor BY55, BY55, Natural Killer Cell Receptor, Immunoglobulin Superfamily Member , CD160 Transmembrane Isoform, CD160-Delta Ig, NK28, NK1, CD160. |
| Source: | Sf9 Insect cells |
| Physical Appearance: | Sterile filtered colorless solution. |
| Formulation: | CD160 protein solution (0.25mg/ml) contains Phosphate Buffered Saline (pH 7.4) and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | ADLINITSSA SQEGTRLNLI CTVWHKKEEA EGFVVFLCKD RSGDCSPETS LKQLRLKRDP GIDGVGEISS QLMFTISQVT PLHSGTYQCC ARSQKSGIRL QGHFFSILFT ETGNYTVTGL KQRQHLEFSH NEGTLSHHHH HH |
CD160 antigen (CD160) is a human natural killer (NK)-cell-activating receptor which is also expressed on T-cell subsets. CD160 is a tumor-specific antigen known to mediate cellular activation signals in CLL, and is a novel target for therapeutic manipulation and monitoring of minimal residual disease. CD160 was identified as a T cell coinhibitory molecule which interacts with the herpesvirus entry mediator (HVEM) on antigen-presenting cells to deliver a potent inhibitory signal to CD4(+) T cells. CD160 expression is strongly associated with peripheral blood NK cells and CD8 T lymphocytes with cytolytic effector activity. CD160 is expressed on all intestinal intraepithelial lymphocytes. CD160 has a broad specificity for binding to both classical and nonclassical MHC class I molecules.
CD160 Human Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 142 amino acids (27-159a.a.) and having a molecular mass of 15.9kDa (Molecular size on SDS-PAGE will appear at approximately 18-28kDa). CD160 is expressed with a 6 amino acids His tag at C-Terminus and purified by proprietary chromatographic techniques.
| UniProt Protein Function: | Receptor showing broad specificity for both classical and non-classical MHC class I molecules. |
| NCBI Summary: | CD160 is an 27 kDa glycoprotein which was initially identified with the monoclonal antibody BY55. Its expression is tightly associated with peripheral blood NK cells and CD8 T lymphocytes with cytolytic effector activity. The cDNA sequence of CD160 predicts a cysteine-rich, glycosylphosphatidylinositol-anchored protein of 181 amino acids with a single Ig-like domain weakly homologous to KIR2DL4 molecule. CD160 is expressed at the cell surface as a tightly disulfide-linked multimer. RNA blot analysis revealed CD160 mRNAs of 1.5 and 1.6 kb whose expression was highly restricted to circulating NK and T cells, spleen and small intestine. Within NK cells CD160 is expressed by CD56dimCD16+ cells whereas among circulating T cells its expression is mainly restricted to TCRgd bearing cells and to TCRab+CD8brightCD95+CD56+CD28-CD27-cells. In tissues, CD160 is expressed on all intestinal intraepithelial lymphocytes. CD160 shows a broad specificity for binding to both classical and nonclassical MHC class I molecules. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O95971 |
| NCBI GenInfo Identifier: | 17372903 |
| NCBI Gene ID: | 11126 |
| NCBI Accession: | O95971.1 |
| UniProt Related Accession: | O95971 |
| Molecular Weight: | 19,810 Da |
| NCBI Full Name: | CD160 antigen |
| NCBI Synonym Full Names: | CD160 molecule |
| NCBI Official Symbol: | CD160�� |
| NCBI Official Synonym Symbols: | NK1; BY55; NK28�� |
| NCBI Protein Information: | CD160 antigen |
| UniProt Protein Name: | CD160 antigen |
| UniProt Synonym Protein Names: | Natural killer cell receptor BY55; CD_antigen: CD160 |
| Protein Family: | CD160 antigen |
| UniProt Gene Name: | CD160�� |
