Human CD2 Recombinant Protein (RPPB3014)
- SKU:
- RPPB3014
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P06729
- Research Area:
- CD Antigens
Description
| Product Name: | Human CD2 Recombinant Protein |
| Product Code: | RPPB3014 |
| Size: | 20µg |
| Species: | Human |
| Target: | CD2 |
| Synonyms: | T-cell surface antigen CD2, T-cell surface antigen T11/Leu-5, LFA-2, LFA-3 receptor, Erythrocyte receptor, Rosette receptor, CD2 antigen, CD2, T11, SRBC. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered clear solution. |
| Formulation: | CD2 protein solution (1mg/ml) containing 20mM Tris-HCl buffer (pH8.0), 10% glycerol and 0.4M Urea. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 85.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMKEITNA LETWGALGQD INLDIPSFQM SDDIDDIKWE KTSDKKKIAQ FRKEKETFKE KDTYKLFKNG TLKIKHLKTD DQDIYKVSIY DTKGKNVLEK IFDLKIQERV SKPKISWTCI NTTLTCEVMN GTDPELNLYQ DGKHLKLSQR VITHKWTTSLSAKFKCTAGN KVSKESSVEP VSCPEKGLD |
CD2 which is also known as E-rosette receptor, T11 and lymphocytefunction antigen-2 (LFA-2) is expressed on T cells, thymocytes, and subset of natural killer cells. Human CD2 functions as the receptor for sheep erythrocytes, human CD58 (LFA-3), and CD15s (Sialyl Lewis X). p56lck, p59fyn, CD3eta and CD3epsilon are tyrosine-phosphorylated after CD2 stimulation. CD2 plays a role in T cell activation, T- or NK-cell-mediated cytolysis, apoptosis in activated peripheral T cells, and regulation of T cell anergy.�
CD2 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 209 amino acids (25-209 a.a) and having a molecular mass of 23.8kDa.CD2 is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | CD2: CD2 interacts with lymphocyte function-associated antigen (LFA-3) and CD48/BCM1 to mediate adhesion between T-cells and other cell types. CD2 is implicated in the triggering of T- cells, the cytoplasmic domain is implicated in the signaling function. |
| UniProt Protein Details: | Protein type:Cell surface; Membrane protein, integral; Apoptosis Chromosomal Location of Human Ortholog: 1p13.1 Cellular Component: anchored to plasma membrane; cell surface; external side of plasma membrane; extracellular region; integral to plasma membrane; intercellular junction; internal side of plasma membrane; plasma membrane Molecular Function:protein binding; protein homodimerization activity; receptor activity; receptor binding Biological Process: apoptosis; cell surface receptor linked signal transduction; cell-cell adhesion; heterotypic cell-cell adhesion; leukocyte migration; lipid raft polarization; natural killer cell activation; positive regulation of myeloid dendritic cell activation; positive regulation of tumor necrosis factor production; regulation of T cell differentiation; T cell activation |
| NCBI Summary: | CD2 is a surface antigen of the human T-lymphocyte lineage that is expressed on all peripheral blood T cells (summarized by Sewell et al., 1986 [PubMed 3490670]). It is one of the earliest T-cell markers, being present on more than 95% of thymocytes; it is also found on some natural killer cells but not on B lymphocytes. Monoclonal antibodies directed against CD2 inhibit the formation of rosettes with sheep erythrocytes, indicating that CD2 is the erythrocyte receptor or is closely associated with it.[supplied by OMIM, Jul 2010] |
| UniProt Code: | P06729 |
| NCBI GenInfo Identifier: | 160370002 |
| NCBI Gene ID: | 914 |
| NCBI Accession: | P06729.2 |
| UniProt Secondary Accession: | P06729,Q96TE5, |
| UniProt Related Accession: | P06729 |
| Molecular Weight: | 39,448 Da |
| NCBI Full Name: | T-cell surface antigen CD2 |
| NCBI Synonym Full Names: | CD2 molecule |
| NCBI Official Symbol: | CD2�� |
| NCBI Official Synonym Symbols: | T11; SRBC; LFA-2�� |
| NCBI Protein Information: | T-cell surface antigen CD2 |
| UniProt Protein Name: | T-cell surface antigen CD2 |
| UniProt Synonym Protein Names: | Erythrocyte receptor; LFA-2; LFA-3 receptor; Rosette receptor; T-cell surface antigen T11/Leu-5; CD_antigen: CD2 |
| Protein Family: | CD2 |
| UniProt Gene Name: | CD2�� |
| UniProt Entry Name: | CD2_HUMAN |
