Human CD226 Recombinant Protein (RPPB3044)
- SKU:
- RPPB3044
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q15762
- Research Area:
- CD Antigens
Description
| Product Name: | Human CD226 Recombinant Protein |
| Product Code: | RPPB3044 |
| Size: | 10µg |
| Species: | Human |
| Target: | CD226 |
| Synonyms: | CD226 antigen, DNAX accessory molecule 1, DNAM-1, CD226, CD226Molecule, CD226 Antigen, DNAX Accessory Molecule 1, DNAM-1, DNAM1, TLineage-Specific Activation Antigen 1 Antigen, Platelet And T Cell ActivationAntigen 1, DNAX Accessory Molecule-1, Adhesion Glycoprotein, TLiSA1,PTA1. |
| Source: | Sf9 Insect cells |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | CD226 protein solution (0.5mg/ml) containing PhosphateBuffered Saline (pH 7.4) and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90% as determined by SDS-PAGE. |
| Amino Acid Sequence: | ADPEEVLWHTSVPFAENMSL ECVYPSMGIL TQVEWFKIGT QQDSIAIFSP THGMVIRKPY AERVYFLNST MASNNMTLFFRNASEDDVGY YSCSLYTYPQ GTWQKVIQVV QSDSFEAAVP SNSHIVSEPG KNVTLTCQPQ MTWPVQAVRWEKIQPRQIDL LTYCNLVHGR NFTSKFPRQIVSNCSHGRWS VIVIPDVTVS DSGLYRCYLQ ASAGENETFV MRLTVAEGKT DNLEPKSCDKTHTCPPCPAP ELLGGPSVFL FPPKPKDTLM ISRTPEVTCV VVDVSHEDPE VKFNWYVDGV EVHNAKTKPREEQYNSTYRV VSVLTVLHQD WLNGKEYKCK VSNKALPAPI EKTISKAKGQPREPQVYTLP PSRDELTKNQVSLTCLVKGF YPSDIAVEWE SNGQPENNYK TTPPVLDSDG SFFLYSKLTV DKSRWQQGNV FSCSVMHEALHNHYTQKSLS LSPGKHHHHH H |
CD226 belongs to the Ig-superfamily containing 2 Ig-like domains of the V-set. CD226 is a 65kDa glycoprotein expressed on the surface NK cells, platelets, monocytes and a subset of T cells. CD226 facilitates cellular adhesion of platelets and megakaryocytic cells to vascular endothelial cells. CD226 also plays a role in megakaryocytic cell maturation.
CD226 Human Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 471 amino acids (19-247a.a) and having a molecular mass of 53.2kDa (Molecular size on SDS-PAGE will appear at approximately 50-70kDa).CD226 is fused to a 239 amino acid hIgG-His-tag at C-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | DNAM-1: Receptor involved in intercellular adhesion, lymphocyte signaling, cytotoxicity and lymphokine secretion mediated by cytotoxic T-lymphocyte (CTL) and NK cell. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Immunoglobulin superfamily; Cell adhesion Chromosomal Location of Human Ortholog: 18q22.3 Cellular Component: cell surface; integral to plasma membrane; plasma membrane; external side of plasma membrane; lipid raft Molecular Function:integrin binding; protein binding; cell adhesion molecule binding; protein kinase binding Biological Process: regulation of immune response; positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target; positive regulation of immunoglobulin mediated immune response; cytokine production; cell recognition; positive regulation of natural killer cell mediated cytotoxicity; cell adhesion; signal transduction; positive regulation of mast cell activation |
| NCBI Summary: | This gene encodes a glycoprotein expressed on the surface of NK cells, platelets, monocytes and a subset of T cells. It is a member of the Ig-superfamily containing 2 Ig-like domains of the V-set. The protein mediates cellular adhesion of platelets and megakaryocytic cells to vascular endothelial cells. The protein also plays a role in megakaryocytic cell maturation. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q15762 |
| NCBI GenInfo Identifier: | 317373338 |
| NCBI Gene ID: | 10666 |
| NCBI Accession: | Q15762.2 |
| UniProt Secondary Accession: | Q15762,B2R818, |
| UniProt Related Accession: | Q15762 |
| Molecular Weight: | |
| NCBI Full Name: | CD226 antigen |
| NCBI Synonym Full Names: | CD226 molecule |
| NCBI Official Symbol: | CD226�� |
| NCBI Official Synonym Symbols: | PTA1; DNAM1; DNAM-1; TLiSA1�� |
| NCBI Protein Information: | CD226 antigen; adhesion glycoprotein; DNAX accessory molecule 1; DNAX accessory molecule-1; platelet and T cell activation antigen 1; T lineage-specific activation antigen 1 antigen |
| UniProt Protein Name: | CD226 antigen |
| UniProt Synonym Protein Names: | DNAX accessory molecule 1 |
| Protein Family: | CD226 antigen |
| UniProt Gene Name: | CD226�� |
| UniProt Entry Name: | CD226_HUMAN |
