Human COMMD6 Recombinant Protein (RPPB3227)
- SKU:
- RPPB3227
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q7Z4G1
Frequently bought together:
Description
| Product Name: | Human COMMD6 Recombinant Protein |
| Product Code: | RPPB3227 |
| Size: | 20µg |
| Species: | Human |
| Target: | COMMD6 |
| Synonyms: | COMM domain-containing protein 6, COMM Domain Containing 6, COMMD6, MSTP076, COMM domain-containing protein 6 isoform b, Acrg. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The COMMD6 solution (1mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 20% glycerol, 0.15M NaCl and 1mM DTT. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMEASSEP PLDAKSDVTN QLVDFQWKLG MAVSSDTCRS LKYPYVAVML KVADHSGQVK TKCFEMTIPQ FQNFYRQFKE IAAVIETV |
COMM Domain Containing (COMMD6) which is a part of the NF-kappa-B -inhibiting proteins, contains one COMM domain. COMMD6 down-regulates the activation of NF-kappa-B and inhibits TNF-induced NFKB1 activation.
COMMD6 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 108 amino acids (1-85) and having a molecular mass of 12kDa.COMMD6 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | COMMD6: Down-regulates activation of NF-kappa-B. Inhibits TNF- induced NFKB1 activation. 2 isoforms of the human protein are produced by alternative splicing.Chromosomal Location of Human Ortholog: 13q22Cellular Component: cytoplasm; nucleusMolecular Function: NF-kappaB binding; protein bindingBiological Process: transcription, DNA-dependent; inhibition of NF-kappaB transcription factor |
| UniProt Protein Details: | |
| NCBI Summary: | COMMD6 belongs to a family of NF-kappa-B (see RELA; MIM 164014)-inhibiting proteins characterized by the presence of a COMM domain (see COMMD1; MIM 607238) (de Bie et al., 2006 [PubMed 16573520]).[supplied by OMIM, Mar 2009] |
| UniProt Code: | Q7Z4G1 |
| NCBI GenInfo Identifier: | 565671780 |
| NCBI Gene ID: | 170622 |
| NCBI Accession: | NP_001274323.1 |
| UniProt Secondary Accession: | Q7Z4G1,Q5TBK4, A6NF28, B7ZLN0 |
| UniProt Related Accession: | Q7Z4G1 |
| Molecular Weight: | 10,908 Da |
| NCBI Full Name: | COMM domain-containing protein 6 isoform c |
| NCBI Synonym Full Names: | COMM domain containing 6 |
| NCBI Official Symbol: | COMMD6�� |
| NCBI Official Synonym Symbols: | Acrg�� |
| NCBI Protein Information: | COMM domain-containing protein 6; Acrg embryonic lethality minimal region ortholog |
| UniProt Protein Name: | COMM domain-containing protein 6 |
| UniProt Synonym Protein Names: | |
| Protein Family: | COMM domain-containing protein |
| UniProt Gene Name: | COMMD6�� |
| UniProt Entry Name: | COMD6_HUMAN |
Related Products
