Human CSNK1A1 Recombinant Protein (RPPB2491)
- SKU:
- RPPB2491
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P48729
- Research Area:
- Enzymes
Description
| Product Name: | Human CSNK1A1 Recombinant Protein |
| Product Code: | RPPB2491 |
| Size: | 20µg |
| Species: | Human |
| Target: | CSNK1A1 |
| Synonyms: | Casein kinase I isoform alpha, CKI-alpha, CK1, CSNK1A1, HLCDGP1, PRO2975. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The CSNK1A1 solution (0.5mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.4M Urea and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 80% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MASSSGSKAE FIVGGKYKLV RKIGSGSFGD IYLAINITNG EEVAVKLESQ KARHPQLLYE SKLYKILQGG VGIPHIRWYG QEKDYNVLVM DLLGPSLEDL FNFCSRRFTM KTVLMLADQM ISRIEYVHTK NFIHRDIKPD NFLMGIGRHC NKLFLIDFGL AKKYRDNRTR QHIPYREDKN LTGTARYASI NAHLGIEQSR RDDMESLGYV LMYFNRTSLP WQGLKAATKK QKYEKISEKK MSTPVEVLCK GFPAEFAMYL NYCRGLRFEE APDYMYLRQL FRILFRTLNH QYDYTFDWTM LKQKAAQQAA SSSGQGQQAQ TPTGKQTDKT KSNMKGF |
Caseine Kinase 1 alpha belongs is a member of the protein kinase superfamily, CK1 Ser/Thr protein kinase family, Casein kinase I subfamily. The CK1 isoforms - alpha, beta, gamma, delta, epsilon and their splice variants are involved in diverse cellular processes including membrane trafficking, circadian rhythm, cell cycle progression, chromosome segregation, apoptosis and cellular differentiation. Possibly CSNK1A1 can phosphorylate a large number of proteins and is involved in Wnt signaling where it phosphorylates CTNNB1 on Ser45. CSNK1A1 also interacts with the Axin complex.
CSNK1A1 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 357 amino acids (1-337) and having a molecular mass of 41kDa. CSNK1A1 is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | CK1A: an ubiquitous protein kinase of the CK1 family. Participates in Wnt signaling. Phosphorylates beta catenin, marking it for beta-TRCp-mediated ubiquitinylation and proteasomal degradation. |
| UniProt Protein Details: | Protein type:Protein kinase, CK1; EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor); Kinase, protein; CK1 group; CK1 family Chromosomal Location of Human Ortholog: 5q32 Cellular Component: beta-catenin destruction complex; centrosome; cytosol; keratin filament; membrane; mRNA cleavage and polyadenylation specificity factor complex; nuclear speck Molecular Function:kinase activity; protein binding; protein kinase activity; protein serine/threonine kinase activity Biological Process: cell surface receptor linked signal transduction; Golgi organization and biogenesis; intermediate filament cytoskeleton organization and biogenesis; peptidyl-serine phosphorylation; phagocytosis; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; proteasomal ubiquitin-dependent protein catabolic process; protein amino acid phosphorylation; regulation of cell shape; Wnt receptor signaling pathway |
| UniProt Code: | P48729 |
| NCBI GenInfo Identifier: | 31077177 |
| NCBI Gene ID: | 1452 |
| NCBI Accession: | P48729.2 |
| UniProt Secondary Accession: | P48729,Q4JJA0, Q5U046, Q5U047, Q6FGA2, Q71TU5, Q96HD2 Q9UDK3, D3DQG0, D3DQG1, |
| UniProt Related Accession: | P48729 |
| Molecular Weight: | 37,567 Da |
| NCBI Full Name: | Casein kinase I isoform alpha |
| NCBI Synonym Full Names: | casein kinase 1 alpha 1 |
| NCBI Official Symbol: | CSNK1A1�� |
| NCBI Official Synonym Symbols: | CK1; CK1a; CKIa; HLCDGP1; PRO2975; HEL-S-77p�� |
| NCBI Protein Information: | casein kinase I isoform alpha |
| UniProt Protein Name: | Casein kinase I isoform alpha |
| UniProt Synonym Protein Names: | CK1 |
| Protein Family: | Casein kinase |
| UniProt Gene Name: | CSNK1A1�� |
| UniProt Entry Name: | KC1A_HUMAN |
