Human DDR2 Recombinant Protein (RPPB2498)
- SKU:
- RPPB2498
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q16832
- Research Area:
- Enzymes
Description
| Product Name: | Human DDR2 Recombinant Protein |
| Product Code: | RPPB2498 |
| Size: | 10µg |
| Species: | Human |
| Target: | DDR2 |
| Synonyms: | Discoidin domain-containing receptor 2, DDR2, MIG20a, NTRKR3, TKT, TYR010, Discoidin Domain Receptor Tyrosine Kinase 2, CD167 antigen-like family member B, Discoidin domain-containing receptor tyrosine kinase 2, Neurotrophic tyrosine kinase, receptor-related 3, Receptor protein-tyrosine kinase TKT, Tyrosine-protein kinase TYRO10, CD_antigen: CD167b. |
| Source: | Sf9 Insect cells |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | DDR2 solution (0.5mg/ml) contains Phosphate Buffered Saline (pH 7.4) and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90% as determined by SDS-PAGE. |
| Amino Acid Sequence: | KAQVNPAICR YPLGMSGGQI PDEDITASSQ WSESTAAKYG RLDSEEGDGA WCPEIPVEPD DLKEFLQIDL HTLHFITLVG TQGRHAGGHG IEFAPMYKIN YSRDGTRWIS WRNRHGKQVL DGNSNPYDIF LKDLEPPIVA RFVRFIPVTD HSMNVCMRVE LYGCVWLDGL VSYNAPAGQQ FVLPGGSIIY LNDSVYDGAV GYSMTEGLGQ LTDGVSGLDD FTQTHEYHVW PGYDYVGWRN ESATNGYIEI MFEFDRIRNF TTMKVHCNNM FAKGVKIFKE VQCYFRSEAS EWEPNAISFP LVLDDVNPSA RFVTVPLHHR MASAIKCQYH FADTWMMFSE ITFQSDAAMY NNSEALPTSP MAPTTYDPML KVDDSNTRLE HHHHHH |
DiscoidinDomain Receptor Tyrosine Kinase 2 (DDR2) which is mostly expressed inmesenchymal cells is a part of the discoidin-like domain containing subfamilyof receptor tyrosine kinases. DDR2 whose ligand is fibrillar collagen ratherthan a growth factor-like peptide is unique among RTKs. DDR2 regulates celldifferentiation, remodeling of the extracellular matrix, cell migration andcell proliferation. DDR2 is also essentialfor normal bone development.
DDR2 Human Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 386 amino acids (22-399a.a) and having a molecular mass of 43.7kDa. (Molecular size on SDS-PAGE will appear at approximately 40-57kDa).DDR2 is fused to 8 amino acid His-tag at C-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | DDR2: This tyrosine kinase receptor for fibrillar collagen mediates fibroblast migration and proliferation. Contributes to cutaneous wound healing. Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; EC 2.7.10.1; Protein kinase, TK; Protein kinase, tyrosine (receptor); Kinase, protein; TK group; DDR family Chromosomal Location of Human Ortholog: 1q23.3 Cellular Component: focal adhesion; integral to plasma membrane; apical plasma membrane; plasma membrane Molecular Function:collagen binding; protein binding; transmembrane receptor protein tyrosine kinase activity; ATP binding Biological Process: extracellular matrix organization and biogenesis; ossification; peptidyl-tyrosine phosphorylation; collagen fibril organization; protein amino acid autophosphorylation; signal transduction; positive regulation of osteoblast differentiation; positive regulation of fibroblast proliferation; biomineral formation; positive regulation of protein kinase activity; positive regulation of transcription factor activity; cell adhesion; regulation of bone mineralization Disease: Spondylometaepiphyseal Dysplasia, Short Limb-hand Type |
| NCBI Summary: | This gene encodes a member of the discoidin domain receptor subclass of the receptor tyrosine kinase (RTKs) protein family. RTKs play a key role in the communication of cells with their microenvironment. The encoded protein is a collagen-induced receptor that activates signal transduction pathways involved in cell adhesion, proliferation, and extracellular matrix remodeling. This protein is expressed in numerous cell types and may alos be involved in wound repair and regulate tumor growth and invasiveness. Mutations in this gene are the cause of short limb-hand type spondylometaepiphyseal dysplasia. [provided by RefSeq, Aug 2017] |
| UniProt Code: | Q16832 |
| NCBI GenInfo Identifier: | 215273969 |
| NCBI Gene ID: | 4921 |
| NCBI Accession: | Q16832.2 |
| UniProt Related Accession: | Q16832 |
| Molecular Weight: | |
| NCBI Full Name: | Discoidin domain-containing receptor 2 |
| NCBI Synonym Full Names: | discoidin domain receptor tyrosine kinase 2 |
| NCBI Official Symbol: | DDR2�� |
| NCBI Official Synonym Symbols: | TKT; WRCN; MIG20a; NTRKR3; TYRO10�� |
| NCBI Protein Information: | discoidin domain-containing receptor 2 |
| UniProt Protein Name: | Discoidin domain-containing receptor 2 |
| UniProt Synonym Protein Names: | CD167 antigen-like family member B; Discoidin domain-containing receptor tyrosine kinase 2; Neurotrophic tyrosine kinase, receptor-related 3; Receptor protein-tyrosine kinase TKT; Tyrosine-protein kinase TYRO10; CD_antigen: CD167b |
| Protein Family: | Discoidin domain-containing receptor |
| UniProt Gene Name: | DDR2�� |
| UniProt Entry Name: | DDR2_HUMAN |
