Human GMFB His Recombinant Protein (RPPB0363)
- SKU:
- RPPB0363
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P60983
- Research Area:
- Neurotrophins
Description
| Product Name: | Human GMFB His Recombinant Protein |
| Product Code: | RPPB0363 |
| Size: | 20µg |
| Species: | Human |
| Target: | GMFB His |
| Synonyms: | GMF, GMF beta. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless clear solution. |
| Formulation: | The GMFB 1mg/ml protein solution contains 20mM Tris-HCL pH-8, 1mM DTT, 0.1M NaCl and 10% Glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. Please avoid freeze thaw cycles. |
| Purity: | Greater than 95.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MSESLVVCDV AEDLVEKLRK FRFRKETNNA AIIMKIDKDK RLVVLDEELE GISPDELKDE LPERQPRFIV YSYKYQHDDG RVSYPLCFIF SSPVGCKPEQ QMMYAGSKNK LVQTAELTKV FEIRNTEDLT EEWLREKLGF FH |
GMFB is part of the GMF subfamily of the larger actin-binding protein ADF family. GMFB is phosphorylated after phorbol ester stimulation, and is crucial for the nervous system. GMFB causes brain cell differentiation, stimulates neural regeneration and inhibits tumor cell proliferation. GMFB overexpression in astrocytes results in the increase of BDNF production. GMFB expression is increased by exercise, thus BDNF is important for exercise-induction of BDNF.
GMFB Human Recombinant produced in E.Coli is a signle, non-glycosylated, polypeptide chain containing 162 amino acids (1-142 a.a.)and having a total molecular mass of 18.8 kDa. GMGB is fused to a 20 amino acid His Tag at N-terminus and is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | GMF-beta: This protein causes differentiation of brain cells, stimulation of neural regeneration, and inhibition of proliferation of tumor cells. Belongs to the actin-binding proteins ADF family. GMF subfamily. |
| UniProt Protein Details: | Protein type:Inhibitor; Motility/polarity/chemotaxis; Actin-binding Chromosomal Location of Human Ortholog: 14q22.2 Molecular Function:enzyme activator activity; protein kinase inhibitor activity; signal transducer activity Biological Process: nervous system development; protein amino acid phosphorylation; signal transduction |
| UniProt Code: | P60983 |
| NCBI GenInfo Identifier: | 46577593 |
| NCBI Gene ID: | 2764 |
| NCBI Accession: | P60983.2 |
| UniProt Secondary Accession: | P60983,P17774, Q9BS35, B2R499, |
| UniProt Related Accession: | P60983 |
| Molecular Weight: | 16,713 Da |
| NCBI Full Name: | Glia maturation factor beta |
| NCBI Synonym Full Names: | glia maturation factor beta |
| NCBI Official Symbol: | GMFB�� |
| NCBI Official Synonym Symbols: | GMF�� |
| NCBI Protein Information: | glia maturation factor beta |
| UniProt Protein Name: | Glia maturation factor beta |
| Protein Family: | Glia maturation factor |
| UniProt Gene Name: | GMFB�� |
| UniProt Entry Name: | GMFB_HUMAN |
