Human GSTO2 Recombinant Protein (RPPB1772)
- SKU:
- RPPB1772
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q9H4Y5
- Research Area:
- Enzymes
Description
| Product Name: | Human GSTO2 Recombinant Protein |
| Product Code: | RPPB1772 |
| Size: | 10µg |
| Species: | Human |
| Target: | GSTO2 |
| Synonyms: | Glutathione S-transferase omega-2, GSTO-2, Glutathione S-transferase omega 2-2, GSTO 2-2, Glutathione-dependent dehydroascorbate reductase, Monomethylarsonic acid reductase, MMA(V) reductase, GSTO2, bA127L20.1. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered clear solution. |
| Formulation: | The GSTO2 solution (0.25mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.1M NaCl and 40% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 85.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMSGDATR TLGKGSQPPG PVPEGLIRIY SMRFCPYSHR TRLVLKAKDI RHEVVNINLR NKPEWYYTKH PFGHIPVLET SQCQLIYESV IACEYLDDAY PGRKLFPYDP YERARQKMLL ELFCKVPHLT KECLVALRCG RECTNLKAAL RQEFSNLEEI LEYQNTTFFG GTCISMIDYL LWPWFERLDV YGILDCVSHT PALRLWISAM KWDPTVCALL MDKSIFQGFL NLYFQNNPNA FDFGLC |
Glutathione S-transferase omega 2 (GSTO2) is a member of the GST superfamily. GSTO2 is involved in catalyzing the reaction of glutathione with a broad range of organic compounds to form thioethers, a process which is vital for the metabolism and detoxification of a variety of xenobiotics and carcinogens. GSTO2 displays glutathione-dependent thiol transferase activity. GSTO2 has a high dehydroascorbate reductase activity and may be a factor in the recycling of ascorbic acid. GSTO2 also participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA). GSTO2 is expressed in an array of tissues, including the liver, kidney, skeletal muscle and prostate, while the strongest expression is seen in the testis.
GSTO2 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 266 amino acids (1-243) and having a molecular mass of 30.6kDa.GSTO2 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | GSTO2: Exhibits glutathione-dependent thiol transferase activity. Has high dehydroascorbate reductase activity and may contribute to the recycling of ascorbic acid. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA). Belongs to the GST superfamily. Omega family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Transferase; EC 1.20.4.2; EC 1.8.5.1; Xenobiotic Metabolism - metabolism by cytochrome P450; EC 2.5.1.18; Other Amino Acids Metabolism - glutathione; Xenobiotic Metabolism - drug metabolism - cytochrome P450 Chromosomal Location of Human Ortholog: 10q25.1 Cellular Component: cytosol Molecular Function:glutathione transferase activity; glutathione dehydrogenase (ascorbate) activity; methylarsonate reductase activity; oxidoreductase activity Biological Process: vitamin metabolic process; xenobiotic metabolic process; L-ascorbic acid metabolic process; water-soluble vitamin metabolic process |
| NCBI Summary: | The protein encoded by this gene is an omega class glutathione S-transferase (GST). GSTs are involved in the metabolism of xenobiotics and carcinogens. Four transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2010] |
| UniProt Code: | Q9H4Y5 |
| NCBI GenInfo Identifier: | 34922124 |
| NCBI Gene ID: | 119391 |
| NCBI Accession: | Q9H4Y5.1 |
| UniProt Secondary Accession: | Q9H4Y5,Q49TW5, Q5GM70, Q5JU15, Q86WP3, A8K771, B4DJW6 E7ESD6, |
| UniProt Related Accession: | Q9H4Y5 |
| Molecular Weight: | 243 |
| NCBI Full Name: | Glutathione S-transferase omega-2 |
| NCBI Synonym Full Names: | glutathione S-transferase omega 2 |
| NCBI Official Symbol: | GSTO2�� |
| NCBI Official Synonym Symbols: | GSTO 2-2; bA127L20.1�� |
| NCBI Protein Information: | glutathione S-transferase omega-2; GSTO-2; MMA(V) reductase; monomethylarsonic acid reductase; glutathione S-transferase omega 2-2; glutathione-S-transferase-like protein; bA127L20.1 (novel glutathione-S-transferase); glutathione-dependent dehydroascorbate reductase |
| UniProt Protein Name: | Glutathione S-transferase omega-2 |
| UniProt Synonym Protein Names: | Glutathione S-transferase omega 2-2; GSTO 2-2; Glutathione-dependent dehydroascorbate reductase (EC:1.8.5.1); Monomethylarsonic acid reductase (EC:1.20.4.2); MMA(V) reductase |
| Protein Family: | Glutathione S-transferase |
| UniProt Gene Name: | GSTO2�� |
| UniProt Entry Name: | GSTO2_HUMAN |
