Human IL21R Recombinant Protein (RPPB0636)
- SKU:
- RPPB0636
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q9HBE5
- Research Area:
- Cytokines
Description
| Product Name: | Human IL21R Recombinant Protein |
| Product Code: | RPPB0636 |
| Size: | 10µg |
| Species: | Human |
| Target: | IL21R |
| Synonyms: | Interleukin 21 Receptor, Novel Interleukin Receptor, IL-21 Receptor, NILR, Interleukin-21 Receptor, CD360 Antigen, IL-21R, CD360. |
| Source: | Sf9 Insect cells |
| Physical Appearance: | Sterile filtered colorless solution. |
| Formulation: | IL21R protein solution (1mg/ml) contains Phosphate buffered saline (pH7.4) and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | CPDLVCYTDY LQTVICILEM WNLHPSTLTL TWQDQYEELK DEATSCSLHR SAHNATHATY TCHMDVFHFM ADDIFSVNIT DQSGNYSQEC GSFLLAESIK PAPPFNVTVT FSGQYNISWR SDYEDPAFYM LKGKLQYELQ YRNRGDPWAV SPRRKLISVD SRSVSLLPLE FRKDSSYELQ VRAGPMPGSS YQGTWSEWSD PVIFQTQSEE LKEVEHHHHH H |
Interleukin-21 receptor, also known as IL21R is a member of the type Icytokine receptors family. IL21R forms a heterodimeric receptor complex withthe common gamma-chain, a receptor subunit which is also shared by thereceptors for interleukin 2, 4, 7, 9, and 15. Furthermore, IL21 receptortransduces the growth promoting signal of IL21, and is significant for theproliferation as well as differentiation of T cells, B cells, and naturalkiller (NK) cells. The ligand binding of IL21 receptor leads to the activationof numerous downstream signaling molecules, including JAK1, JAK3, STAT1, aswell as STAT3.
IL21R produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain (20-232 a.a.) and fused to an 8 aa His Tag at C-terminus containing a total of 221 amino acids and having a molecular mass of 25.6kDa.IL21R shows multiple bands between 28-40kDa on SDS-PAGE, reducing conditions and purified by proprietary chromatographic techniques.
| UniProt Protein Function: | IL21R: This is a receptor for interleukin-21 |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Receptor, cytokine Chromosomal Location of Human Ortholog: 16p11 Cellular Component: integral to membrane Molecular Function:interleukin-21 receptor activity Biological Process: natural killer cell activation Disease: Ige Responsiveness, Atopic; Il21r Immunodeficiency |
| NCBI Summary: | The protein encoded by this gene is a cytokine receptor for interleukin 21 (IL21). It belongs to the type I cytokine receptors, and has been shown to form a heterodimeric receptor complex with the common gamma-chain, a receptor subunit also shared by the receptors for interleukin 2, 4, 7, 9, and 15. This receptor transduces the growth promoting signal of IL21, and is important for the proliferation and differentiation of T cells, B cells, and natural killer (NK) cells. The ligand binding of this receptor leads to the activation of multiple downstream signaling molecules, including JAK1, JAK3, STAT1, and STAT3. Knockout studies of a similar gene in mouse suggest a role for this gene in regulating immunoglobulin production. Three alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2010] |
| UniProt Code: | Q9HBE5 |
| NCBI GenInfo Identifier: | 20454997 |
| NCBI Gene ID: | 50615 |
| NCBI Accession: | Q9HBE5.1 |
| UniProt Secondary Accession: | Q9HBE5,Q96HZ1, Q9HB91, A8K9E8, D3DWF7, |
| UniProt Related Accession: | Q9HBE5 |
| Molecular Weight: | 538 |
| NCBI Full Name: | Interleukin-21 receptor |
| NCBI Synonym Full Names: | interleukin 21 receptor |
| NCBI Official Symbol: | IL21R�� |
| NCBI Official Synonym Symbols: | NILR; CD360�� |
| NCBI Protein Information: | interleukin-21 receptor; IL-21 receptor; novel interleukin receptor |
| UniProt Protein Name: | Interleukin-21 receptor |
| UniProt Synonym Protein Names: | Novel interleukin receptor; CD_antigen: CD360 |
| Protein Family: | Interleukin-21 receptor |
| UniProt Gene Name: | IL21R�� |
| UniProt Entry Name: | IL21R_HUMAN |
